biostudies-literatureUnknown8(3)Kim CRPrompt administration of first-aid drugs can save lives during medical emergencies such as anaphylaxis and hypoglycemia. However, this is often performed by needle self-injection, which is not easy for patients under emergency conditions. Therefore, we propose an implantable device capable of on-demand administration of first-aid drugs (i.e., the implantable device with a magnetically rotating disk [iMRD]), such as epinephrine and glucagon, via a noninvasive simple application of the magnet from the outside skin (i.e., the external magnet). The iMRD contained a disk embedded with a magnet, as well as multiple drug reservoirs that were sealed with a membrane, which was designed to rotate at a precise angle only when the external magnet was applied. During this rotation, the membrane on a deBioengineering & translational medicinee10479https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189441biostudies-literatureImplantable device with magnetically rotating disk for needle-free administrations of emergency drug.PMC10189441Cho YCLee CKim CRChoy YBJi HBKim SNKim MJMin CHHan JHfalseImplantable device with magnetically rotating disk for needle-free administrations of emergency drug.Prompt administration of first-aid drugs can save lives during medical emergencies such as anaphylaxis and hypoglycemia. However, this is often performed by needle self-injection, which is not easy for patients under emergency conditions. Therefore, we propose an implantable device capable of on-demand administration of first-aid drugs (i.e., the implantable device with a magnetically rotating disk [iMRD]), such as epinephrine and glucagon, via a noninvasive simple application of the magnet from the outside skin (i.e., the external magnet). The iMRD contained a disk embedded with a magnet, as well as multiple drug reservoirs that were sealed with a membrane, which was designed to rotate at a precise angle only when the external magnet was applied. During this rotation, the membrane on a de2023-01-01T00:00:00Z2023 May2025-04-05T10:55:27.057Z2025-04-05T10:55:27.057ZS-EPMC101894413720622510.1002/btm2.10479