{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(3)"],"submitter":["Yi J"],"pubmed_abstract":["Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn-CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP-ribose) polymerase inhibitors for lethal effects."],"journal":["Bioengineering & translational medicine"],"pagination":["e10507"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189445"],"repository":["biostudies-literature"],"pubmed_title":["Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair."],"pmcid":["PMC10189445"],"pubmed_authors":["Yi J","Qiao G","Xing J","Lin X","Gedanken A","Luo X","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.","description":"Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn-CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP-ribose) polymerase inhibitors for lethal effects.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-26T14:26:25.84Z","creation":"2025-04-06T14:36:31.959Z"},"accession":"S-EPMC10189445","cross_references":{"pubmed":["37206208"],"doi":["10.1002/btm2.10507"]}}