{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(6)"],"submitter":["Piya S"],"pubmed_abstract":["Gene co-expression network analysis is an efficient systems biology approach for the discovery of novel gene functions and trait-associated gene modules. To identify clusters of functionally related genes involved in soybean nodule formation and development, we performed a weighted gene co-expression network analysis. Two nodule-specific modules (NSM-1 and NSM-2, containing 304 and 203 genes, respectively) were identified. The NSM-1 gene promoters were significantly enriched in cis-binding elements for ERF, MYB, and C2H2-type zinc transcription factors, whereas NSM-2 gene promoters were enriched in cis-binding elements for TCP, bZIP, and bHLH transcription factors, suggesting a role of these regulatory factors in the transcriptional activation of nodule co-expressed genes. The co-expressed"],"journal":["Molecular plant pathology"],"pagination":["628-636"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10189762"],"repository":["biostudies-literature"],"pubmed_title":["Soybean gene co-expression network analysis identifies two co-regulated gene modules associated with nodule formation and development."],"pmcid":["PMC10189762"],"pubmed_authors":["Lakhssassi N","Zadegan SB","Krishnan HB","Piya S","Pantalone V","Meksem K","Knizia D","Hewezi T","Shipp S"],"additional_accession":[]},"is_claimable":false,"name":"Soybean gene co-expression network analysis identifies two co-regulated gene modules associated with nodule formation and development.","description":"Gene co-expression network analysis is an efficient systems biology approach for the discovery of novel gene functions and trait-associated gene modules. To identify clusters of functionally related genes involved in soybean nodule formation and development, we performed a weighted gene co-expression network analysis. Two nodule-specific modules (NSM-1 and NSM-2, containing 304 and 203 genes, respectively) were identified. The NSM-1 gene promoters were significantly enriched in cis-binding elements for ERF, MYB, and C2H2-type zinc transcription factors, whereas NSM-2 gene promoters were enriched in cis-binding elements for TCP, bZIP, and bHLH transcription factors, suggesting a role of these regulatory factors in the transcriptional activation of nodule co-expressed genes. The co-expressed","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-05T16:14:21.608Z","creation":"2025-04-05T16:14:21.608Z"},"accession":"S-EPMC10189762","cross_references":{"pubmed":["36975024"],"doi":["10.1111/mpp.13327"]}}