biostudies-literatureDeng YNon-profit Central Research Institution Fund of Chinese Academy of Medical SciencesNational Natural Science Foundation of ChinaSanming Project of Medicine in ShenzhenCAMS Innovation Fund for Medical Sciences (CIFMS), China131https://www.ebi.ac.uk/biostudies/studies/S-EPMC10190004biostudies-literatureUnknown23(1)<h4>Background</h4>To explore the clinical prognostic utility of the preoperative cholesterol-to-lymphocyte ratio (CLR) in outcomes for colorectal cancer liver metastasis (CRLM) patients receiving simultaneous resection of the primary lesion and liver metastases.<h4>Methods</h4>A total of 444 CRLM patients receiving simultaneous resections were enrolled. The optimal cut-off value for CLR was determined using the highest Youden's index. Patients were divided into the CLR < 3.06 group and the CLR≥3.06 group. Propensity score matching analysis (PSM) and the inverse probability of treatment weighting (IPTW) method were conducted to eliminate bias between the two groups. The outcomes included short-term outcomes and long-term outcomes. Kaplan-Meier curves and log-rank tests were used to analyseBMC surgeryAn elevated preoperative cholesterol-to-lymphocyte ratio predicts unfavourable outcomes in colorectal cancer liver metastasis patients receiving simultaneous resections: a retrospective study.PMC10190004No. 81972311, 82141127No. 2019PT310026No. SZSM202011010No. 2021-I2M-1-066Bi XChen QLi ZChen JHuang ZZhang YCai JZhao JDeng YZhao HfalseAn elevated preoperative cholesterol-to-lymphocyte ratio predicts unfavourable outcomes in colorectal cancer liver metastasis patients receiving simultaneous resections: a retrospective study.<h4>Background</h4>To explore the clinical prognostic utility of the preoperative cholesterol-to-lymphocyte ratio (CLR) in outcomes for colorectal cancer liver metastasis (CRLM) patients receiving simultaneous resection of the primary lesion and liver metastases.<h4>Methods</h4>A total of 444 CRLM patients receiving simultaneous resections were enrolled. The optimal cut-off value for CLR was determined using the highest Youden's index. Patients were divided into the CLR < 3.06 group and the CLR≥3.06 group. Propensity score matching analysis (PSM) and the inverse probability of treatment weighting (IPTW) method were conducted to eliminate bias between the two groups. The outcomes included short-term outcomes and long-term outcomes. Kaplan-Meier curves and log-rank tests were used to analyse2023-01-01T00:00:00Z2023 May2025-04-22T14:50:25.524Z2025-04-06T01:06:45.544ZS-EPMC101900043719400010.1186/s12893-023-01988-7