{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu L"],"funding":["Technische Universität München","Guangzhou Science and Technology Program","Technical University of Munich","the President funds of Integrated Hospital of Traditional Chinese Medicine, Southern Medical University","Guangdong Basic and Applied Basic Research Foundation","Natural Science Foundation of Guangdong Province"],"pagination":["e2203423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10190571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(14)"],"pubmed_abstract":["The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly understood. In the present study, the expression and function of non-muscle myosin heavy chain IIB (MYH10) in SOC are identified by immunohistochemistry, in vitro, and in vivo studies, respectively. The mechanism of MYH10 is demonstrated by co-immunoprecipitation, GST pull-down, confocal laser assays, and so on. The results show that the knockdown of MYH10 suppressed SOC cell proliferation, migration, invasion, metastasis, and cisplatin resistance both in vivo and in vitro. Further studies confirm that the MYH10 protein functional domain combines with non-muscle myosin heavy chain IIA (MYH9) to recruit the deubiquitinat"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance."],"pmcid":["PMC10190571"],"funding_grant_id":["1201902001：1201901002","2020A1515110030","202102080060","2020A1515010284"],"pubmed_authors":["Li J","Liu L","Xie Y","Liu P","Zeng Z","Pang Z","Lin Z","Chen C","Chen ZS","Lan T","Zhu J","Fang W","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"MYH10 Combines with MYH9 to Recruit USP45 by Deubiquitinating Snail and Promotes Serous Ovarian Cancer Carcinogenesis, Progression, and Cisplatin Resistance.","description":"The poor prognosis of serous ovarian cancer (SOC) is due to its high invasive capacity and cisplatin resistance of SOC cells, whereas the molecular mechanisms remain poorly understood. In the present study, the expression and function of non-muscle myosin heavy chain IIB (MYH10) in SOC are identified by immunohistochemistry, in vitro, and in vivo studies, respectively. The mechanism of MYH10 is demonstrated by co-immunoprecipitation, GST pull-down, confocal laser assays, and so on. The results show that the knockdown of MYH10 suppressed SOC cell proliferation, migration, invasion, metastasis, and cisplatin resistance both in vivo and in vitro. Further studies confirm that the MYH10 protein functional domain combines with non-muscle myosin heavy chain IIA (MYH9) to recruit the deubiquitinat","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-06-02T21:54:11.77Z","creation":"2025-04-07T01:47:27.291Z"},"accession":"S-EPMC10190571","cross_references":{"pubmed":["36929633"],"doi":["10.1002/advs.202203423"]}}