{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stensland ZC"],"funding":["Network for Pancreatic Organ Donors","Leona M. and Harry B. Helmsley Charitable Trust","NIDDK NIH HHS","National Institutes of Health","JDRF","NIH HHS"],"pagination":["e20221604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10192302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["220(8)"],"pubmed_abstract":["Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We performed a cross-sectional analysis comparing insulin-reactive to tetanus-reactive B cells in the blood of T1D and controls using mass cytometry. Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defined anergic BND subset. We found a specific increase in the frequency of insulin-reactive BND2 cells in the blood of young-onset T1D donors, which was further enriched in the pancreatic lymph nodes of T1D donors. The frequency of insulin-binding BND2 cells correlated with a"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients."],"pmcid":["PMC10192302"],"funding_grant_id":["P30DK116073","K01OD028759","P30 DK116073","R03 DK129925","R03DK129925","R03 OD036470","G-2108-04793","2018PG-T1D053","K01 OD028759"],"pubmed_authors":["Stensland ZC","Wells KL","Smith MJ","Rihanek M","Rios-Guzman NM","Gottlieb PA","Gomez BD","Nicholas CA","Hunter MJ","Magera CA","Toole KP","Broncucia H"],"additional_accession":[]},"is_claimable":false,"name":"Identification of an anergic BND cell-derived activated B cell population (BND2) in young-onset type 1 diabetes patients.","description":"Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1 diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the specificity, phenotype, and function of B cells in young-onset T1D. We performed a cross-sectional analysis comparing insulin-reactive to tetanus-reactive B cells in the blood of T1D and controls using mass cytometry. Unsupervised clustering revealed the existence of a highly activated B cell subset we term BND2 that falls within the previously defined anergic BND subset. We found a specific increase in the frequency of insulin-reactive BND2 cells in the blood of young-onset T1D donors, which was further enriched in the pancreatic lymph nodes of T1D donors. The frequency of insulin-binding BND2 cells correlated with a","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2026-04-29T02:24:05.795Z","creation":"2024-11-07T02:43:21.178Z"},"accession":"S-EPMC10192302","cross_references":{"pubmed":["37184563"],"doi":["10.1084/jem.20221604"]}}