{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lockhart A"],"funding":["Food Allergy FARE/FASI Consortium","Howard Hughes Medical Institute"],"pagination":["e20221816"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10192604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["220(8)"],"pubmed_abstract":["The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at the intestinal epithelium, imprinting a tissue-specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs). This steady state CD4+ T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased proi"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells."],"pmcid":["PMC10192604"],"funding_grant_id":["R01DK113375","R01DK093674","R21AI144827"],"pubmed_authors":["Rezende de Castro T","Campos Canesso MC","Mucida D","Herman C","Lockhart A","Reed A"],"additional_accession":[]},"is_claimable":false,"name":"Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells.","description":"The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at the intestinal epithelium, imprinting a tissue-specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs). This steady state CD4+ T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased proi","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Aug","modification":"2025-04-04T23:45:03.346Z","creation":"2025-04-04T23:45:03.346Z"},"accession":"S-EPMC10192604","cross_references":{"pubmed":["37191720"],"doi":["10.1084/jem.20221816"]}}