biostudies-literatureBattistoni ALigue Contre le Cancere006683https://www.ebi.ac.uk/biostudies/studies/S-EPMC10193056biostudies-literatureUnknown11(5)<h4>Background</h4>Metastases are the leading cause of mortality in many cancer types and lungs are one of the most common sites of metastasis alongside the liver, brain, and bones. In melanoma, 85% of late-stage patients harbor lung metastases. A local administration could enhance the targeting of metastases while limiting the systemic cytotoxicity. Therefore, intranasal administration of immunotherapeutic agents seems to be a promising approach to preferentially target lung metastases and decrease their burden on cancer mortality. From observations that certain microorganisms induce an acute infection of the tumor microenvironment leading to a local reactivating immune response, microbial-mediated immunotherapy is a next-generation field of investigation in which immunotherapies are engiJournal for immunotherapy of cancerNasal administration of recombinant <i>Neospora caninum</i> secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung.PMC10193056LigueContreLeCancer2019Mevelec MNdi Tommaso ALajoie LRiviere CBattistoni ADimier-Poisson ISamimi MDucournau CLee GSMoire NGermon SHertereau LPoupee-Beauge AEpardaud MRieu JLantier LCoenon LfalseNasal administration of recombinant <i>Neospora caninum</i> secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung.<h4>Background</h4>Metastases are the leading cause of mortality in many cancer types and lungs are one of the most common sites of metastasis alongside the liver, brain, and bones. In melanoma, 85% of late-stage patients harbor lung metastases. A local administration could enhance the targeting of metastases while limiting the systemic cytotoxicity. Therefore, intranasal administration of immunotherapeutic agents seems to be a promising approach to preferentially target lung metastases and decrease their burden on cancer mortality. From observations that certain microorganisms induce an acute infection of the tumor microenvironment leading to a local reactivating immune response, microbial-mediated immunotherapy is a next-generation field of investigation in which immunotherapies are engi2023-01-01T00:00:00Z2023 May2026-07-14T20:57:54.674Z2026-06-24T03:07:06.94ZS-EPMC101930563719278410.1136/jitc-2023-006683