{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lampert R"],"funding":["NCATS NIH HHS","NHLBI NIH HHS","Medical Research Council","Wellcome Trust"],"pagination":["595-605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10193262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(6)"],"pubmed_abstract":["<h4>Importance</h4>Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown.<h4>Objective</h4>To determine whether engagement in vigorous exercise is associated with increased risk for ventricular arrhythmias and/or mortality in individuals with HCM. The a priori hypothesis was that participants engaging in vigorous activity were not more likely to have an arrhythmic event or die than those who reported nonvigorous activity.<h4>Design, setting, and participants</h4>This was an investigator-initiated, prospective cohort study. Participants were enrolled from May 18, 2015, to April 25, 2019, with completion in February 28, 2022. Participants were categorized according to self-reporte"],"journal":["JAMA cardiology"],"pubmed_title":["Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy."],"pmcid":["PMC10193262"],"funding_grant_id":["MC_UP_1102/20","R01 HL125918","UL1 TR001863","107469/Z/15/Z"],"pubmed_authors":["Ackerman MJ","Salberg L","Shah M","Eidem B","Rao R","Simone L","Bos M","Cooper R","Saarel EV","Berul CI","Nandi D","Abrahms D","Cerrone M","Abraham R","Ware JS","Masri A","Molossi S","Olshansky B","Ashley E","Wever-Pinzon O","Czosek RJ","Dziura J","Kanter R","Ommen SR","Hall K","LIVE Consortium","Webster G","Ho CY","Skinner J","Li F","Zipes DP","Ainsworth B","Link MS","McKenna WJ","Aziz P","Ferhaan A","Emery MS","Tomaselli G","Concannon M","Murphy A","Li W","Geske JB","Law IH","Sanatani S","Estes NAM","Choudhury L","Lal AK","Colan S","James CA","Harmon KG","Burg M","Gollob MJ","Barth C","Rosenthal D","Turer A","Balaji S","Erickson C","Johnsrude C","Tardif J","Perez M","Marino BS","Wong T","Cannom D","Saberi S","Perry J","Dubin AM","Towbin J","Day SM","Kannankeril P","Lampert R","Tome Esteban MT","Semsarian C","Etheridge SP","Gray B","Popjes E","Batra A"],"additional_accession":[]},"is_claimable":false,"name":"Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy.","description":"<h4>Importance</h4>Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown.<h4>Objective</h4>To determine whether engagement in vigorous exercise is associated with increased risk for ventricular arrhythmias and/or mortality in individuals with HCM. The a priori hypothesis was that participants engaging in vigorous activity were not more likely to have an arrhythmic event or die than those who reported nonvigorous activity.<h4>Design, setting, and participants</h4>This was an investigator-initiated, prospective cohort study. Participants were enrolled from May 18, 2015, to April 25, 2019, with completion in February 28, 2022. Participants were categorized according to self-reporte","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-18T14:33:33.652Z","creation":"2025-04-07T00:45:49.802Z"},"accession":"S-EPMC10193262","cross_references":{"pubmed":["37195701"],"doi":["10.1001/jamacardio.2023.1042"]}}