biostudies-literatureLampert RNCATS NIH HHSNHLBI NIH HHSMedical Research CouncilWellcome Trust595-605https://www.ebi.ac.uk/biostudies/studies/S-EPMC10193262biostudies-literatureUnknown8(6)<h4>Importance</h4>Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown.<h4>Objective</h4>To determine whether engagement in vigorous exercise is associated with increased risk for ventricular arrhythmias and/or mortality in individuals with HCM. The a priori hypothesis was that participants engaging in vigorous activity were not more likely to have an arrhythmic event or die than those who reported nonvigorous activity.<h4>Design, setting, and participants</h4>This was an investigator-initiated, prospective cohort study. Participants were enrolled from May 18, 2015, to April 25, 2019, with completion in February 28, 2022. Participants were categorized according to self-reporteJAMA cardiologyVigorous Exercise in Patients With Hypertrophic Cardiomyopathy.PMC10193262MC_UP_1102/20R01 HL125918UL1 TR001863107469/Z/15/ZAckerman MJSalberg LShah MEidem BRao RSimone LBos MCooper RSaarel EVBerul CINandi DAbrahms DCerrone MAbraham RWare JSMasri AMolossi SOlshansky BAshley EWever-Pinzon OCzosek RJDziura JKanter ROmmen SRHall KLIVE ConsortiumWebster GHo CYSkinner JLi FZipes DPAinsworth BLink MSMcKenna WJAziz PFerhaan AEmery MSTomaselli GConcannon MMurphy ALi WGeske JBLaw IHSanatani SEstes NAMChoudhury LLal AKColan SJames CAHarmon KGBurg MGollob MJBarth CRosenthal DTurer ABalaji SErickson CJohnsrude CTardif JPerez MMarino BSWong TCannom DSaberi SPerry JDubin AMTowbin JDay SMKannankeril PLampert RTome Esteban MTSemsarian CEtheridge SPGray BPopjes EBatra AfalseVigorous Exercise in Patients With Hypertrophic Cardiomyopathy.<h4>Importance</h4>Whether vigorous intensity exercise is associated with an increase in risk of ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown.<h4>Objective</h4>To determine whether engagement in vigorous exercise is associated with increased risk for ventricular arrhythmias and/or mortality in individuals with HCM. The a priori hypothesis was that participants engaging in vigorous activity were not more likely to have an arrhythmic event or die than those who reported nonvigorous activity.<h4>Design, setting, and participants</h4>This was an investigator-initiated, prospective cohort study. Participants were enrolled from May 18, 2015, to April 25, 2019, with completion in February 28, 2022. Participants were categorized according to self-reporte2023-01-01T00:00:00Z2023 Jun2025-04-18T14:33:33.652Z2025-04-07T00:45:49.802ZS-EPMC101932623719570110.1001/jamacardio.2023.1042