{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(19)"],"submitter":["Chi X"],"pubmed_abstract":["In pursuit of developing novel azole antifungals with potent activity and high selectivity, a series of (2<i>R</i>,3<i>S</i>)-3-(substituted-1<i>H</i>-pyrazol-3-yl)-2-(2,4-difluorophenyl)-1-(1<i>H</i>-tetrazol-1-yl)butan-2-ol derivatives were designed and synthesized based on our previous work. All compounds exhibited excellent <i>in vitro</i> antifungal activities against <i>Candida</i> spp. and <i>Cryptococcus neoformans</i> H99 with minimum inhibitory concentration values ranging from <0.008 to 4 μg/mL, with some even showing moderate activity against <i>Aspergillus fumigatus</i> 7544. The most active compounds (<b>8</b>, <b>11</b>, <b>15</b>, <b>24</b>, and <b>25)</b> displayed outstanding antifungal activity against six fluconazole-resistant <i>C. auris</i> clinical isolates and showe"],"journal":["ACS omega"],"pagination":["17103-17115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10193422"],"repository":["biostudies-literature"],"pubmed_title":["Discovery of Novel Tetrazoles Featuring a Pyrazole Moiety as Potent and Highly Selective Antifungal Agents."],"pmcid":["PMC10193422"],"pubmed_authors":["Jiang Y","Li X","Zhang H","Ni T","Chi X","Li L","Wu H"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of Novel Tetrazoles Featuring a Pyrazole Moiety as Potent and Highly Selective Antifungal Agents.","description":"In pursuit of developing novel azole antifungals with potent activity and high selectivity, a series of (2<i>R</i>,3<i>S</i>)-3-(substituted-1<i>H</i>-pyrazol-3-yl)-2-(2,4-difluorophenyl)-1-(1<i>H</i>-tetrazol-1-yl)butan-2-ol derivatives were designed and synthesized based on our previous work. All compounds exhibited excellent <i>in vitro</i> antifungal activities against <i>Candida</i> spp. and <i>Cryptococcus neoformans</i> H99 with minimum inhibitory concentration values ranging from <0.008 to 4 μg/mL, with some even showing moderate activity against <i>Aspergillus fumigatus</i> 7544. The most active compounds (<b>8</b>, <b>11</b>, <b>15</b>, <b>24</b>, and <b>25)</b> displayed outstanding antifungal activity against six fluconazole-resistant <i>C. auris</i> clinical isolates and showe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-26T21:30:36.745Z","creation":"2025-04-06T16:47:43.654Z"},"accession":"S-EPMC10193422","cross_references":{"pubmed":["37214706"],"doi":["10.1021/acsomega.3c01421"]}}