biostudies-literatureUnknown11Salis FInnovative Medicines InitiativeEuropean Federation of Pharmaceutical Industries and AssociationsHorizon 2020Wellcome Trust<b>Introduction:</b> Accurately assessing people's gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related digital mobility outcomes (DMOs) in real-world scenarios, this study presents a wearable multi-sensor system (INDIP), integrating complementary sensing approaches (two plantar pressure insoles, three inertial units and two distance sensors). <b>Methods:</b> The INDIP technical validity was assessed against stereophotogrammetry during a laboratory experimental protocol comprising structured tests (including continuous curvilinear and rectilinear walking and steps) and a simulation of daily-life activities (including intermittent gait anFrontiers in bioengineering and biotechnology1143248https://www.ebi.ac.uk/biostudies/studies/S-EPMC10194657biostudies-literatureA multi-sensor wearable system for the assessment of diseased gait in real-world conditions.PMC10194657Salis FEskofier BMBuckley EMaetzler WKluge FDel Din SAlcock LCereatti AScott KGarcia-Aymerich JSchwickert LD'Ascanio IHume ECCaruso MPalmerini LKuederle ADella Croce UCarsin AESingleton DGazit EKoch SSharrack BHansen CKirk CMazza CBertuletti SAminian KMueller ANeatrour IChiari LBrown PRochester LVereijken BVogiatzis ICaulfield BHausdorff JMBonci TFor The Mobilise-D ConsortiumBecker CMico-Amigo EMParaschiv-Ionescu AYarnall AJfalseA multi-sensor wearable system for the assessment of diseased gait in real-world conditions.<b>Introduction:</b> Accurately assessing people's gait, especially in real-world conditions and in case of impaired mobility, is still a challenge due to intrinsic and extrinsic factors resulting in gait complexity. To improve the estimation of gait-related digital mobility outcomes (DMOs) in real-world scenarios, this study presents a wearable multi-sensor system (INDIP), integrating complementary sensing approaches (two plantar pressure insoles, three inertial units and two distance sensors). <b>Methods:</b> The INDIP technical validity was assessed against stereophotogrammetry during a laboratory experimental protocol comprising structured tests (including continuous curvilinear and rectilinear walking and steps) and a simulation of daily-life activities (including intermittent gait an2023-01-01T00:00:00Z20232026-06-03T21:28:14.177Z2025-04-06T16:48:29.351ZS-EPMC101946573721428110.3389/fbioe.2023.1143248