{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Paisana E"],"funding":["Fundação para a Ciência e a Tecnologia"],"pagination":["vdad048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10195208"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(1)"],"pubmed_abstract":["<h4>Background</h4>Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies.<h4>Methods</h4>Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identified the upregulation of <i>UBE2C</i>, a gene that ensures the correct transition from metaphase to anaphase, across different primary tumor origins.<h4>Results</h4>Tissue microarray analysis of an independent BM patient cohort revealed that high expression of UBE2C was associated with decreased survival. UBE2C-driven orthotopic mouse models developed extensive leptomeningeal dissemination, likely due to increased migration and invasion. Early cancer treatment with dactolisib (dual P"],"journal":["Neuro-oncology advances"],"pubmed_title":["UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease."],"pmcid":["PMC10195208"],"funding_grant_id":["PD/BD/128288/2017","PTDC/MEDONC/"],"pubmed_authors":["Roque R","Qin N","Picard D","Cascao R","Pauck D","Doutel D","Pimentel J","Ruivo P","Remke M","Barreto C","Paisana E","Cabecadas J","Custodia C","Miguens J","Faria CC","Carvalho T","Barata JT"],"additional_accession":[]},"is_claimable":false,"name":"UBE2C promotes leptomeningeal dissemination and is a therapeutic target in brain metastatic disease.","description":"<h4>Background</h4>Despite current improvements in systemic cancer treatment, brain metastases (BM) remain incurable, and there is an unmet clinical need for effective targeted therapies.<h4>Methods</h4>Here, we sought common molecular events in brain metastatic disease. RNA sequencing of thirty human BM identified the upregulation of <i>UBE2C</i>, a gene that ensures the correct transition from metaphase to anaphase, across different primary tumor origins.<h4>Results</h4>Tissue microarray analysis of an independent BM patient cohort revealed that high expression of UBE2C was associated with decreased survival. UBE2C-driven orthotopic mouse models developed extensive leptomeningeal dissemination, likely due to increased migration and invasion. Early cancer treatment with dactolisib (dual P","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Dec","modification":"2026-05-28T22:59:55.615Z","creation":"2025-04-04T23:44:41.208Z"},"accession":"S-EPMC10195208","cross_references":{"pubmed":["37215954"],"doi":["10.1093/noajnl/vdad048"]}}