biostudies-literatureUnknown11Magill EB<h4>Background</h4>The HADITHI study is a cluster-randomized trial of children living with HIV and their caregivers in Kenya that aimed to increase rates of caregiver disclosure of their child's HIV status, encourage earlier status disclosure, and improve pediatric mental health and HIV outcomes. This analysis identified characteristics predicting caregiver non-responsiveness and compared outcomes among children based on disclosure status.<h4>Methods</h4>A penalized logistic regression model with lasso regularization identified the most important predictors of disclosure. The two-stage least squares instrumental variable approach was used to assess outcomes accounting for non-compliance to disclosure.<h4>Results</h4>Caregiver non-isolation and shorter time on antiretroviral therapy were prFrontiers in public health1150744https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196043biostudies-literatureFactors associated with caregiver compliance to an HIV disclosure intervention and its effect on HIV and mental health outcomes among children living with HIV: <i>post-hoc</i> instrumental variable-based analysis of a cluster randomized trial in Eldoret, Kenya.PMC10196043Scanlon MSang FAluoch JAshimoshi CNyandiko WVreeman RNyagaya JHogan JBaum ALidweye JChory ANjoroge TMagill EBfalseFactors associated with caregiver compliance to an HIV disclosure intervention and its effect on HIV and mental health outcomes among children living with HIV: <i>post-hoc</i> instrumental variable-based analysis of a cluster randomized trial in Eldoret, Kenya.<h4>Background</h4>The HADITHI study is a cluster-randomized trial of children living with HIV and their caregivers in Kenya that aimed to increase rates of caregiver disclosure of their child's HIV status, encourage earlier status disclosure, and improve pediatric mental health and HIV outcomes. This analysis identified characteristics predicting caregiver non-responsiveness and compared outcomes among children based on disclosure status.<h4>Methods</h4>A penalized logistic regression model with lasso regularization identified the most important predictors of disclosure. The two-stage least squares instrumental variable approach was used to assess outcomes accounting for non-compliance to disclosure.<h4>Results</h4>Caregiver non-isolation and shorter time on antiretroviral therapy were pr2023-01-01T00:00:00Z20232025-04-27T04:36:41.737Z2025-04-06T19:07:15.825ZS-EPMC101960433721365410.3389/fpubh.2023.1150744