{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Klose V"],"pubmed_abstract":["<h4>Introduction</h4>Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.<h4>Methods</h4>IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively colle"],"journal":["Frontiers in neurology"],"pagination":["1170360"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196068"],"repository":["biostudies-literature"],"pubmed_title":["CSF oligoclonal IgG bands are not associated with ALS progression and prognosis."],"pmcid":["PMC10196068"],"pubmed_authors":["Ludolph AC","Kassubek J","Klose V","Roselli F","Lewerenz J","Dorst J","Jesse S","Tumani H"],"additional_accession":[]},"is_claimable":false,"name":"CSF oligoclonal IgG bands are not associated with ALS progression and prognosis.","description":"<h4>Introduction</h4>Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.<h4>Methods</h4>IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively colle","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T23:45:01.028Z","creation":"2025-04-04T23:45:01.028Z"},"accession":"S-EPMC10196068","cross_references":{"pubmed":["37213901"],"doi":["10.3389/fneur.2023.1170360"]}}