biostudies-literatureUnknown14Klose V<h4>Introduction</h4>Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.<h4>Methods</h4>IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively colleFrontiers in neurology1170360https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196068biostudies-literatureCSF oligoclonal IgG bands are not associated with ALS progression and prognosis.PMC10196068Ludolph ACKassubek JKlose VRoselli FLewerenz JDorst JJesse STumani HfalseCSF oligoclonal IgG bands are not associated with ALS progression and prognosis.<h4>Introduction</h4>Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive motoneuron degeneration through cell autonomous and non-cell autonomous mechanisms; and the involvement of the innate and adaptive immune system has been hypothesized based on human and murine model data. We have explored if B-cell activation and IgG responses, as detected by IgG Oligoclonal bands (OCB) in serum and cerebrospinal fluid, were associated with ALS or with a subgroup of patients with distinct clinical features.<h4>Methods</h4>IgG OCB were determined in patients affected by ALS (n=457), Alzheimer Disease (n=516), Mild Cognitive Impairment (n=91), Tension-type Headache (n=152) and idiopathic Facial Palsy (n=94). For ALS patients, clinico-demographic and survival data were prospectively colle2023-01-01T00:00:00Z20232025-04-04T23:45:01.028Z2025-04-04T23:45:01.028ZS-EPMC101960683721390110.3389/fneur.2023.1170360