{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Campelo SN"],"pubmed_abstract":["<h4>Background</h4>Irreversible electroporation (IRE) has been previously investigated in preclinical trials as a treatment for intracranial malignancies. Here, we investigate next generation high-frequency irreversible electroporation (H-FIRE), as both a monotherapy and a combinatorial therapy, for the treatment of malignant gliomas.<h4>Methods</h4>Hydrogel tissue scaffolds and numerical modeling were used to inform <i>in-vivo</i> H-FIRE pulsing parameters for our orthotopic tumor-bearing glioma model. Fischer rats were separated into five treatment cohorts including high-dose H-FIRE (1750V/cm), low-dose H-FIRE (600V/cm), combinatorial high-dose H-FIRE + liposomal doxorubicin, low-dose H-FIRE + liposomal doxorubicin, and standalone liposomal doxorubicin groups. Cohorts were compared again"],"journal":["Frontiers in oncology"],"pagination":["1171278"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196182"],"repository":["biostudies-literature"],"pubmed_title":["High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas."],"pmcid":["PMC10196182"],"pubmed_authors":["Garcia J","Thomas SC","Saunier S","Verbridge SS","Rossmeisl JH","Lorenzo MF","Partridge B","Campelo SN","Hinckley J","Alinezhadbalalami N","Kani Y","Davalos RV"],"additional_accession":[]},"is_claimable":false,"name":"High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas.","description":"<h4>Background</h4>Irreversible electroporation (IRE) has been previously investigated in preclinical trials as a treatment for intracranial malignancies. Here, we investigate next generation high-frequency irreversible electroporation (H-FIRE), as both a monotherapy and a combinatorial therapy, for the treatment of malignant gliomas.<h4>Methods</h4>Hydrogel tissue scaffolds and numerical modeling were used to inform <i>in-vivo</i> H-FIRE pulsing parameters for our orthotopic tumor-bearing glioma model. Fischer rats were separated into five treatment cohorts including high-dose H-FIRE (1750V/cm), low-dose H-FIRE (600V/cm), combinatorial high-dose H-FIRE + liposomal doxorubicin, low-dose H-FIRE + liposomal doxorubicin, and standalone liposomal doxorubicin groups. Cohorts were compared again","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T21:25:44.165Z","creation":"2025-04-06T16:50:19.241Z"},"accession":"S-EPMC10196182","cross_references":{"pubmed":["37213298"],"doi":["10.3389/fonc.2023.1171278"]}}