{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen B"],"funding":["NIDDK NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["104691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196865"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["299(5)"],"pubmed_abstract":["Mitophagy is a cargo-specific autophagic process that recycles damaged mitochondria to promote mitochondrial turnover. PTEN-induced putative kinase 1 (PINK1) mediates the canonical mitophagic pathway. However, the role of PINK1 in diseases where mitophagy has been purported to play a role, such as colorectal cancer, is unclear. Our results here demonstrate that higher PINK1 expression is positively correlated with decreased colon cancer survival, and mitophagy is required for colon cancer growth. We show that doxycycline-inducible knockdown (KD) of PINK1 in a panel of colon cancer cell lines inhibited proliferation, whereas disruption of other mitophagy receptors did not impact cell growth. We observed that PINK KD led to a decrease in mitochondrial respiration, membrane hyperpolarization,"],"journal":["The Journal of biological chemistry"],"pubmed_title":["PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool."],"pmcid":["PMC10196865"],"funding_grant_id":["R01 CA244931","R01 CA248160","P30 CA046592","R01 DK095201","T32 GM145470","R01 CA148828","P30 DK034933","R01 DK124384","R01 CA245546","R37 CA237421"],"pubmed_authors":["Andren A","Das NK","Talukder I","Singhal R","Castillo C","Shah YM","Chen B","Lyssiotis CA","Mancias JD"],"additional_accession":[]},"is_claimable":false,"name":"PTEN-induced kinase PINK1 supports colorectal cancer growth by regulating the labile iron pool.","description":"Mitophagy is a cargo-specific autophagic process that recycles damaged mitochondria to promote mitochondrial turnover. PTEN-induced putative kinase 1 (PINK1) mediates the canonical mitophagic pathway. However, the role of PINK1 in diseases where mitophagy has been purported to play a role, such as colorectal cancer, is unclear. Our results here demonstrate that higher PINK1 expression is positively correlated with decreased colon cancer survival, and mitophagy is required for colon cancer growth. We show that doxycycline-inducible knockdown (KD) of PINK1 in a panel of colon cancer cell lines inhibited proliferation, whereas disruption of other mitophagy receptors did not impact cell growth. We observed that PINK KD led to a decrease in mitochondrial respiration, membrane hyperpolarization,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-07-14T22:13:56.56Z","creation":"2025-04-04T02:54:07.509Z"},"accession":"S-EPMC10196865","cross_references":{"pubmed":["37037306"],"doi":["10.1016/j.jbc.2023.104691"]}}