biostudies-literatureUnknown6(5)Patel H<h4>Importance</h4>Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. Understanding the role of autoantibodies in these conditions is essential for guiding MIS-C management and vaccination strategies in children.<h4>Objective</h4>To investigate the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis.<h4>Design, setting, and participants</h4>This diagnostic study included children with acute MIS-C or acute vaccine myocarditis, adults with myocarditis or inflammatory cardiomyopathy, healthy children prior to the COVID-19 pandemic, and healthy COVID-19 vaccinated adults. Participants were recruited into research studies in the US, United Kingdom,JAMA network opene2314291https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196878biostudies-literatureEvaluation of Autoantibody Binding to Cardiac Tissue in Multisystem Inflammatory Syndrome in Children and COVID-19 Vaccination-Induced Myocarditis.PMC10196878Sancho-Shimizu VPlankar Srovin TZimmermann EFidler KNewall KNdure EVoice MBracken ACalvez RPolz LSchroepf SGardiner EKuijpers TWDummer KEnsom RPokhrel BGruppen MGutierrez LRomaine SPatel HVermont CLHaas NFernandez SSRudzate ALinforth MBeckley RTaylor ACeolotto ASagmeister MGRomani LRojo PAgyeman PMadelane MDivakaran DGonzalez FABerger CKitanovski LShen CFAbdulla AMarmarinos AFitchett EWhite MKelly SZachariasse JBojang KAggelos PAebi CHamilton SZavadska DBogovic PSchoen CTreloar OMaritsi DUrbieta ADRelly CSeal MMiller DWhite DMiller CBath DVijlbrief DCSchobi NCabello LDanekova NMavridi IBurns JCNijman Rvan Furth MGiannoni EPosfay-Barbe KMCohen LMarquez SWallner ENichols SHude CWellman PBenesch Mvan der Zee CVincek KRusu APaulus SCMachin FRajic GCunnington AAvramoska TBernhard-Stirnemann SSchranz RCohen JLaivacuma SKohlfurst DSPilch HCresswell FMichalis VManzano JRSvilz DKolnik MSchonenberg DKeren IBinder ADIAMONDS consortiumRichmond VGautam MCPapst LHernandez ISchluchter SDavis FLoffler SEber EPeters MCarter MStocker MRodl SBroderick CBories PEvans BVerkuil FDewez MMallah NChiurchiu SPennisi IWellings LDaubney EEvans CEllis DRobbins CAvcin TBauchinger SChowdhury RADe TGormley SO'Reilly PLachaume NPokorn MTkhayat RPfurtscheller KKeldorfer MHeightman MHagedoorn NNCotillon MBont LJReid RStevens JTissing WJECarrol EDTripiciano CHolden JSaidykhan MKhalid NJackson HSalas ALenihan REpalza CBeer STsolia MSpyridis NHopton SVazquez SRWeber KMustafa SVergnault NRoca ARedondo-Collazo LBell AGijon MKahlert CXagorari MAgranoff DSchofield JLevin MHauer AJarman HBijukchhe SMBell KD'Souza GTambouratzi MDik WKohlmaier BEisen SLim EVastert SJMartinon JMSarr IStoiser BMaier ETibby SNasher MSuarez CDvan den Berg MYeung Svan der Flier MShah PNagelkerke SPollard AJEstrada-Rivadeneyra DWosten-van Asperen RMGriese MHanson AAlba-Alejandre ICharalambos GWallia DHaidl HOwen DBellini AMoser NKhanijau AScholefield BMatthews PBranch NWright VJB Drysdale SKapper AIsaacs JStrenger VGurung MRial JGBeudeker CRRodriguez-Tenreiro CHoffmann FIglesias MVSkrabl-Baumgartner ARainer PPVillaverde SDanhauser KBello XMercadante SMcKay SDavies CPardo-Seco JWhittaker Evon Both UFeuchtinger THan LCaro IDavoust JIoanna SBasmaci RMoradi Marjaneh MThomas DBahovec NGomez-Carballa ACocklin EOng KTStrempfl MThomson EShankar-Hari MSimagan TBrengel-Pesce KWomersley RTremoulet AHRiddell APischedda SShenton GKaforou MPowell OGravele DGomez SACurras-Tuala MJSee HMeier MGeorgiou PHeininger USchmied Pvan Hensbroek MBAmatya PIglesias PLMalcolm ILGarcia MBKenny JKavanagh JGallistl SPajkrt DFink CLiebeschuetz SMenikou SFaust SHamzah LWilson CEmonts MCapozzi LCrulley SAnthony MPrice AVicente LGShackley FJansen MZurl CHosele SVito OO'Neill LSegal TKolberg LPanagiota LCheriaux LWinmill HPrasad SO'Riordan SNeshat SDe Luca MKappler MHerberg JFabian DManzanares ACalvo-Bado LPathan Nde Tugny AJennings AZenz WShaji MCarnota SHabgood-Coote DVidal IFBilling KMoots RUsuf Evan der Velden FJSLe SSteele MTan CMartinon-Torres NTauchert MKRothery SNahtigal MSattler SPfleger AMartinon-Torres FBarzdina AShrestha SWard BBarzdina ELurz ESanchez BMPLeitner MBiesbroek GNatalucci GStoldere DRiedel TWyss VRughnani PSchweintzger NAChannon-Wells SBorensztajn DMCalle IRFish MUsman MNyirenda MWhitbread JKarolina AJuranek SShimizu CBamford AEstramiana Elorrieta LEleftheriou IMoll HAAnpananthar AStrle FReiter KDarnell SDeep AOliver ZVina FCMarkos Mde Groc TGoetschalckx IGalassini RMommert-Tripon MSintou ABellos ESchlapbach LJSchlapbach LCooray SLewis-Burke NIacob AONiedrist TNiederer-Loher Avan de Kuip MfalseEvaluation of Autoantibody Binding to Cardiac Tissue in Multisystem Inflammatory Syndrome in Children and COVID-19 Vaccination-Induced Myocarditis.<h4>Importance</h4>Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) and vaccines against SARS-CoV-2. Understanding the role of autoantibodies in these conditions is essential for guiding MIS-C management and vaccination strategies in children.<h4>Objective</h4>To investigate the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis.<h4>Design, setting, and participants</h4>This diagnostic study included children with acute MIS-C or acute vaccine myocarditis, adults with myocarditis or inflammatory cardiomyopathy, healthy children prior to the COVID-19 pandemic, and healthy COVID-19 vaccinated adults. Participants were recruited into research studies in the US, United Kingdom,2023-01-01T00:00:00Z2023 May2025-04-22T00:33:41.912Z2025-04-22T00:33:41.912ZS-EPMC101968783720002810.1001/jamanetworkopen.2023.14291