biostudies-literatureUnknown6(5)Harris KM<h4>Importance</h4>Pain related to sickle cell disease (SCD) is complex and associated with social determinants of health. Emotional and stress-related effects of SCD impact daily quality of life and the frequency and severity of pain.<h4>Objective</h4>To explore the association of educational attainment, employment status, and mental health with pain episode frequency and severity among individuals with SCD.<h4>Design, setting, and participants</h4>This is a cross-sectional analysis of patient registry data collected at baseline (2017-2018) from patients treated at 8 sites of the US Sickle Cell Disease Implementation Consortium. Data analysis was performed from September 2020 to March 2022.<h4>Main outcomes and measures</h4>Electronic medical record abstraction and a participant survey prJAMA network opene2314070https://www.ebi.ac.uk/biostudies/studies/S-EPMC10196879biostudies-literatureExamining Mental Health, Education, Employment, and Pain in Sickle Cell Disease.PMC10196879Hussain FACalhoun CLMelvin CLGibson RHarris KMBauer APreiss LHankins JSMasese RSickle Cell Disease Implementation ConsortiumGlassberg JKing AAVarughese TTreadwell MfalseExamining Mental Health, Education, Employment, and Pain in Sickle Cell Disease.<h4>Importance</h4>Pain related to sickle cell disease (SCD) is complex and associated with social determinants of health. Emotional and stress-related effects of SCD impact daily quality of life and the frequency and severity of pain.<h4>Objective</h4>To explore the association of educational attainment, employment status, and mental health with pain episode frequency and severity among individuals with SCD.<h4>Design, setting, and participants</h4>This is a cross-sectional analysis of patient registry data collected at baseline (2017-2018) from patients treated at 8 sites of the US Sickle Cell Disease Implementation Consortium. Data analysis was performed from September 2020 to March 2022.<h4>Main outcomes and measures</h4>Electronic medical record abstraction and a participant survey pr2023-01-01T00:00:00Z2023 May2025-04-25T22:36:20.929Z2025-04-06T09:05:00.644ZS-EPMC101968793720003310.1001/jamanetworkopen.2023.14070