biostudies-literatureHan CJWomen&apos;s Health Initiativee0286058https://www.ebi.ac.uk/biostudies/studies/S-EPMC10198480biostudies-literatureUnknown18(5)<h4>Purpose</h4>Colorectal cancer (CRC) survivors often experience long-term symptoms after cancer treatments. But gastrointestinal (GI) symptom experiences are under-investigated in CRC survivors. We described persistent GI symptoms after cancer treatments in female CRC survivors and assessed GI symptoms' risk and life-impact factors.<h4>Methods</h4>A cross-sectional study utilized data from the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study that recruited postmenopausal women. Correlation analyses and multivariable linear regression models were used.<h4>Results</h4>CRC survivors after cancer treatments were included (N = 413, mean age 71.2 years old, mean time since diagnosis = 8.1 years). 81% of CRC survivors experienced persistent GI symptoms. Bloating/gaPloS oneFactors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women's health initiatives (WHI study).PMC1019848075N92021D00001, 75N92021D00002, 75N92021D00003, 75N92021D00004, 75N92021D00005.Reding KWHan CJYung RKalady MFPaskett EDGreenlee HfalseFactors associated with long-term gastrointestinal symptoms in colorectal cancer survivors in the women's health initiatives (WHI study).<h4>Purpose</h4>Colorectal cancer (CRC) survivors often experience long-term symptoms after cancer treatments. But gastrointestinal (GI) symptom experiences are under-investigated in CRC survivors. We described persistent GI symptoms after cancer treatments in female CRC survivors and assessed GI symptoms' risk and life-impact factors.<h4>Methods</h4>A cross-sectional study utilized data from the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) study that recruited postmenopausal women. Correlation analyses and multivariable linear regression models were used.<h4>Results</h4>CRC survivors after cancer treatments were included (N = 413, mean age 71.2 years old, mean time since diagnosis = 8.1 years). 81% of CRC survivors experienced persistent GI symptoms. Bloating/ga2023-01-01T00:00:00Z20232025-04-05T10:54:34.487Z2025-04-05T10:54:34.487ZS-EPMC101984803720566710.1371/journal.pone.0286058