{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["Ministry of Science and Technology of the People's Republic of China","Guangdong Key R & D Project","Department of Education of Guangdong Province","Shenzhen Special Fund for Sustainable Development","the Key Laboratory of Mariculture of Ministry of Education, Ocean University of China","Shenzhen University 2035 Initiative","National Natural Science Foundation of China"],"pagination":["84"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10199484"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Diatoms have been viewed as ideal cell factories for production of some high-value bioactive metabolites, such as fucoxanthin, but their applications are restrained by limited biomass yield. Mixotrophy, by using both CO<sub>2</sub> and organic carbon source, is believed effective to crack the bottleneck of biomass accumulation and achieve a sustainable bioproduct supply.<h4>Results</h4>Glycerol, among tested carbon sources, was proved as the sole that could significantly promote growth of Cylindrotheca sp. with illumination, a so-called growth pattern, mixotrophy. Biomass and fucoxanthin yields of Cylindrotheca sp., grown in medium with glycerol (2 g L<sup>-1</sup>), was increased by 52% and 29%, respectively, as compared to the autotrophic culture (control) without comp"],"journal":["Biotechnology for biofuels and bioproducts"],"pubmed_title":["Transcriptomic and metabolomic analyses revealed regulation mechanism of mixotrophic Cylindrotheca sp. glycerol utilization and biomass promotion."],"pmcid":["PMC10199484"],"funding_grant_id":["2022B1111070005","2018YFA0902500","2022B010","2022KQNCX065","32273118","KLM202204","KCXFZ20211020164013021"],"pubmed_authors":["Zhao M","Hu Z","Wang S","Wu S","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic and metabolomic analyses revealed regulation mechanism of mixotrophic Cylindrotheca sp. glycerol utilization and biomass promotion.","description":"<h4>Background</h4>Diatoms have been viewed as ideal cell factories for production of some high-value bioactive metabolites, such as fucoxanthin, but their applications are restrained by limited biomass yield. Mixotrophy, by using both CO<sub>2</sub> and organic carbon source, is believed effective to crack the bottleneck of biomass accumulation and achieve a sustainable bioproduct supply.<h4>Results</h4>Glycerol, among tested carbon sources, was proved as the sole that could significantly promote growth of Cylindrotheca sp. with illumination, a so-called growth pattern, mixotrophy. Biomass and fucoxanthin yields of Cylindrotheca sp., grown in medium with glycerol (2 g L<sup>-1</sup>), was increased by 52% and 29%, respectively, as compared to the autotrophic culture (control) without comp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-27T01:33:53.021Z","creation":"2025-04-06T18:18:57.915Z"},"accession":"S-EPMC10199484","cross_references":{"pubmed":["37208696"],"doi":["10.1186/s13068-023-02338-8"]}}