{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yan S"],"funding":["Beijing Medical Award Foundation Key Project","Social Development Project of Yangzhou Science and Technology Bureau"],"pagination":["683-694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10199981"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["<h4>Introduction</h4>Rocuronium intravenous pain is common in induction of general anesthesia. The aim of our study was to determine the median effective dose (ED<sub>50</sub>) of prophylactic intravenous remifentanil for the prevention of rocuronium injection pain and to explore the effect of age on the ED<sub>50</sub>.<h4>Methods</h4>Eighty-nine adult patients undergoing elective general anesthesia, ASA I or II, regardless of gender or weight, were stratified according to age: group R1 18-44 years, group R2 45-59 years, and group R3 60-80 years. The initial dose of prophylactic remifentanil before rocuronium injection was set at 1 μg/kg lean body weight (LBW). The remifentanil doses were adjusted according to the degree of injection pain using the Dixon sequential method, with a ratio of"],"journal":["Pain and therapy"],"pubmed_title":["Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium: An Age-Stratified Study."],"pmcid":["PMC10199981"],"funding_grant_id":["YXJL-2021-0307-0632","YZ2022108"],"pubmed_authors":["Li H","Yu L","Zhang D","Zhang Z","Yan S","Wang Y","Wu H","Yu Y","Li N"],"additional_accession":[]},"is_claimable":false,"name":"Median Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium: An Age-Stratified Study.","description":"<h4>Introduction</h4>Rocuronium intravenous pain is common in induction of general anesthesia. The aim of our study was to determine the median effective dose (ED<sub>50</sub>) of prophylactic intravenous remifentanil for the prevention of rocuronium injection pain and to explore the effect of age on the ED<sub>50</sub>.<h4>Methods</h4>Eighty-nine adult patients undergoing elective general anesthesia, ASA I or II, regardless of gender or weight, were stratified according to age: group R1 18-44 years, group R2 45-59 years, and group R3 60-80 years. The initial dose of prophylactic remifentanil before rocuronium injection was set at 1 μg/kg lean body weight (LBW). The remifentanil doses were adjusted according to the degree of injection pain using the Dixon sequential method, with a ratio of","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T13:07:42.853Z","creation":"2025-04-04T13:07:42.853Z"},"accession":"S-EPMC10199981","cross_references":{"pubmed":["36884108"],"doi":["10.1007/s40122-023-00490-5"]}}