biostudies-literatureYan SBeijing Medical Award Foundation Key ProjectSocial Development Project of Yangzhou Science and Technology Bureau683-694https://www.ebi.ac.uk/biostudies/studies/S-EPMC10199981biostudies-literatureUnknown12(3)<h4>Introduction</h4>Rocuronium intravenous pain is common in induction of general anesthesia. The aim of our study was to determine the median effective dose (ED₅₀) of prophylactic intravenous remifentanil for the prevention of rocuronium injection pain and to explore the effect of age on the ED₅₀.<h4>Methods</h4>Eighty-nine adult patients undergoing elective general anesthesia, ASA I or II, regardless of gender or weight, were stratified according to age: group R1 18-44 years, group R2 45-59 years, and group R3 60-80 years. The initial dose of prophylactic remifentanil before rocuronium injection was set at 1 μg/kg lean body weight (LBW). The remifentanil doses were adjusted according to the degree of injection pain using the Dixon sequential method, with a ratio ofPain and therapyMedian Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium: An Age-Stratified Study.PMC10199981YXJL-2021-0307-0632YZ2022108Li HYu LZhang DZhang ZYan SWang YWu HYu YLi NfalseMedian Effective Dose of Remifentanil for the Prevention of Pain Caused by the Injection of Rocuronium: An Age-Stratified Study.<h4>Introduction</h4>Rocuronium intravenous pain is common in induction of general anesthesia. The aim of our study was to determine the median effective dose (ED₅₀) of prophylactic intravenous remifentanil for the prevention of rocuronium injection pain and to explore the effect of age on the ED₅₀.<h4>Methods</h4>Eighty-nine adult patients undergoing elective general anesthesia, ASA I or II, regardless of gender or weight, were stratified according to age: group R1 18-44 years, group R2 45-59 years, and group R3 60-80 years. The initial dose of prophylactic remifentanil before rocuronium injection was set at 1 μg/kg lean body weight (LBW). The remifentanil doses were adjusted according to the degree of injection pain using the Dixon sequential method, with a ratio of2023-01-01T00:00:00Z2023 Jun2025-04-04T13:07:42.853Z2025-04-04T13:07:42.853ZS-EPMC101999813688410810.1007/s40122-023-00490-5