biostudies-literatureUnknown15(2)Schliep KC<h4>Introduction</h4>Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.<h4>Methods</h4>Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women.<h4>Results</h4>Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk.<h4>Discussion</h4>Improved HDP and mid-life care could reduce the risk of dementia.Alzheimer's & dementia (Amsterdam, Netherlands)e12443https://www.ebi.ac.uk/biostudies/studies/S-EPMC10201212biostudies-literatureHypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.PMC10201212Sharma SWactawski-Wende JShaaban CEMeeks HMajersik JJSchliep KCOstbye TSmith KRFraser APadbury JFTschanz JAbdelrahman CSZhang YFacelli JCVarner MWTheilen LFoster NLfalseHypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.<h4>Introduction</h4>Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.<h4>Methods</h4>Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women.<h4>Results</h4>Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk.<h4>Discussion</h4>Improved HDP and mid-life care could reduce the risk of dementia.2023-01-01T00:00:00Z2023 Apr-Jun2025-04-05T14:38:20.204Z2025-04-05T14:38:20.204ZS-EPMC102012123722333410.1002/dad2.12443