{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Akanda MR"],"funding":["National Research Foundation of Korea","Chonnam National University Hospital Biomedical Research Institute"],"pagination":["468"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10201734"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investigated the relationship between the expression of stromal CAF markers in metastatic sites, platelet-derived growth factor receptor-beta (PDGFR-β), and alpha-smooth muscle actin (α-SMA) and the clinical and prognostic variables in BCBM patients.<h4>Methods</h4>Immunohistochemistry (IHC) of the stromal expression of PDGFR-β and α-SMA was performed on 50 cases of surgically resected BCBM. The expression of the CAF markers was analyzed in the context of clinico-pathological characteristics.<h4>Results</h4>Expression of PDGFR-β and α-SMA was lower in t"],"journal":["BMC cancer"],"pubmed_title":["Analysis of stromal PDGFR-β and α-SMA expression and their clinical relevance in brain metastases of breast cancer patients."],"pmcid":["PMC10201734"],"funding_grant_id":["2022R1A2C1011889, 2020R1A5A2031185, 2020R1C1C1007832","HCRI21001, HCRI21005"],"pubmed_authors":["Kim SS","Lee TK","Noh MG","Kim YJ","Ahn EJ","Salam SMA","Akanda MR","Lee KH","Moon KS"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of stromal PDGFR-β and α-SMA expression and their clinical relevance in brain metastases of breast cancer patients.","description":"<h4>Background</h4>Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investigated the relationship between the expression of stromal CAF markers in metastatic sites, platelet-derived growth factor receptor-beta (PDGFR-β), and alpha-smooth muscle actin (α-SMA) and the clinical and prognostic variables in BCBM patients.<h4>Methods</h4>Immunohistochemistry (IHC) of the stromal expression of PDGFR-β and α-SMA was performed on 50 cases of surgically resected BCBM. The expression of the CAF markers was analyzed in the context of clinico-pathological characteristics.<h4>Results</h4>Expression of PDGFR-β and α-SMA was lower in t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-04T10:27:43.111Z","creation":"2025-04-04T10:27:43.111Z"},"accession":"S-EPMC10201734","cross_references":{"pubmed":["37217880"],"doi":["10.1186/s12885-023-10957-5"]}}