biostudies-literatureAkanda MRNational Research Foundation of KoreaChonnam National University Hospital Biomedical Research Institute468https://www.ebi.ac.uk/biostudies/studies/S-EPMC10201734biostudies-literatureUnknown23(1)<h4>Background</h4>Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investigated the relationship between the expression of stromal CAF markers in metastatic sites, platelet-derived growth factor receptor-beta (PDGFR-β), and alpha-smooth muscle actin (α-SMA) and the clinical and prognostic variables in BCBM patients.<h4>Methods</h4>Immunohistochemistry (IHC) of the stromal expression of PDGFR-β and α-SMA was performed on 50 cases of surgically resected BCBM. The expression of the CAF markers was analyzed in the context of clinico-pathological characteristics.<h4>Results</h4>Expression of PDGFR-β and α-SMA was lower in tBMC cancerAnalysis of stromal PDGFR-β and α-SMA expression and their clinical relevance in brain metastases of breast cancer patients.PMC102017342022R1A2C1011889, 2020R1A5A2031185, 2020R1C1C1007832HCRI21001, HCRI21005Kim SSLee TKNoh MGKim YJAhn EJSalam SMAAkanda MRLee KHMoon KSfalseAnalysis of stromal PDGFR-β and α-SMA expression and their clinical relevance in brain metastases of breast cancer patients.<h4>Background</h4>Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases. Herein, we investigated the relationship between the expression of stromal CAF markers in metastatic sites, platelet-derived growth factor receptor-beta (PDGFR-β), and alpha-smooth muscle actin (α-SMA) and the clinical and prognostic variables in BCBM patients.<h4>Methods</h4>Immunohistochemistry (IHC) of the stromal expression of PDGFR-β and α-SMA was performed on 50 cases of surgically resected BCBM. The expression of the CAF markers was analyzed in the context of clinico-pathological characteristics.<h4>Results</h4>Expression of PDGFR-β and α-SMA was lower in t2023-01-01T00:00:00Z2023 May2025-04-04T10:27:43.111Z2025-04-04T10:27:43.111ZS-EPMC102017343721788010.1186/s12885-023-10957-5