{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Kielholz T"],"funding":["Johann Wolfgang Goethe-Universität, Frankfurt am Main"],"pubmed_abstract":["The increasing incidence of infected skin wounds poses a major challenge in clinical practice, especially when conventional antibiotic therapy fails. In this context, bacteriophages emerged as promising alternatives for the treatment of antibiotic-resistant bacteria. However, clinical implementation remains hampered by the lack of efficient delivery approaches to infected wound tissue. In this study, bacteriophage-loaded electrospun fiber mats were successfully developed as next-generation wound dressings for the treatment of infected wounds. We employed a coaxial electrospinning approach, creating fibers with a protective polymer shell, enveloping bacteriophages in the core while maintaining their antimicrobial activity. The novel fibers exhibited a reproducible fiber diameter range and m"],"journal":["Scientific reports"],"pagination":["8330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10205809"],"repository":["biostudies-literature"],"pubmed_title":["Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections."],"pmcid":["PMC10205809"],"pubmed_authors":["Rohde F","Jung N","Windbergs M","Kielholz T"],"additional_accession":[]},"is_claimable":false,"name":"Bacteriophage-loaded functional nanofibers for treatment of P. aeruginosa and S. aureus wound infections.","description":"The increasing incidence of infected skin wounds poses a major challenge in clinical practice, especially when conventional antibiotic therapy fails. In this context, bacteriophages emerged as promising alternatives for the treatment of antibiotic-resistant bacteria. However, clinical implementation remains hampered by the lack of efficient delivery approaches to infected wound tissue. In this study, bacteriophage-loaded electrospun fiber mats were successfully developed as next-generation wound dressings for the treatment of infected wounds. We employed a coaxial electrospinning approach, creating fibers with a protective polymer shell, enveloping bacteriophages in the core while maintaining their antimicrobial activity. The novel fibers exhibited a reproducible fiber diameter range and m","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-06T19:16:38.357Z","creation":"2025-04-06T19:16:38.357Z"},"accession":"S-EPMC10205809","cross_references":{"pubmed":["37221194"],"doi":["10.1038/s41598-023-35364-5"]}}