{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Guo Y"],"pubmed_abstract":["MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been related to adverse drug reactions. Moreover, a role has been proposed in asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. Although it has a prominent role in disease, its signaling transduction is poorly understood. This study shows that MRGPRX2 activation with substance P increased Lysyl t-RNA synthetase (LysRS) translocation to the nucleus. LysRS is a moonlighting protein with a dual role in protein translation and IgE signaling in mast cells. Upon allergen- IgE-FcεRI crosslinking, LysRS is translocated t"],"journal":["Frontiers in immunology"],"pagination":["1154108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10206166"],"repository":["biostudies-literature"],"pubmed_title":["MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway."],"pmcid":["PMC10206166"],"pubmed_authors":["Olle L","Guo Y","Proano-Perez E","Guerrero M","Munoz-Cano R","Martin M","Aparicio C"],"additional_accession":[]},"is_claimable":false,"name":"MRGPRX2 signaling involves the Lysyl-tRNA synthetase and MITF pathway.","description":"MRGPRX2, a G-protein-coupled-seven transmembrane domain receptor, is mainly expressed in mast cells and neurons and is involved in skin immunity and pain. It is implicated in the pathophysiology of non-IgE-mediated immediate hypersensitivity and has been related to adverse drug reactions. Moreover, a role has been proposed in asthma, atopic dermatitis, contact dermatitis, and chronic spontaneous urticaria. Although it has a prominent role in disease, its signaling transduction is poorly understood. This study shows that MRGPRX2 activation with substance P increased Lysyl t-RNA synthetase (LysRS) translocation to the nucleus. LysRS is a moonlighting protein with a dual role in protein translation and IgE signaling in mast cells. Upon allergen- IgE-FcεRI crosslinking, LysRS is translocated t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-19T06:22:10.2Z","creation":"2025-04-19T06:22:10.2Z"},"accession":"S-EPMC10206166","cross_references":{"pubmed":["37234172"],"doi":["10.3389/fimmu.2023.1154108"]}}