{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Sun J"],"pubmed_abstract":["Background
Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals.Methods
A total of 302 participants were randomized to LC diet (n = 76), CR diet (n = 75), LC + CR diet (n = 76), or normal control (NC) diet (n = 75) using a computer-based random number generator. The primary outcome was the change in body mass index (BMI). The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health ed"],"journal":["BMC medicine"],"pagination":["192"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10210464"],"repository":["biostudies-literature"],"pubmed_title":["The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial."],"pmcid":["PMC10210464"],"pubmed_authors":["Ruan Y","Liang Y","Wu P","Lu Z","Zhang H","Su J","Huang Q","Deng G","Wen W","Ma W","Kang P","Chen X","Wang Y","Yingzhang","Sun J","An S","Xu N","Yuan K","Chen H","Chen B","Li Y","Li S","Zhang Z","Zhang X","Lin N"],"additional_accession":[]},"is_claimable":false,"name":"The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial.","description":"Background
Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals.Methods
A total of 302 participants were randomized to LC diet (n = 76), CR diet (n = 75), LC + CR diet (n = 76), or normal control (NC) diet (n = 75) using a computer-based random number generator. The primary outcome was the change in body mass index (BMI). The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health ed","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-21T21:21:00.893Z","creation":"2025-04-05T18:18:31.695Z"},"accession":"S-EPMC10210464","cross_references":{"pubmed":["37226271"],"doi":["10.1186/s12916-023-02869-9"]}}