biostudies-literatureUnknown21(1)Sun J<h4>Background</h4>Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals.<h4>Methods</h4>A total of 302 participants were randomized to LC diet (n = 76), CR diet (n = 75), LC + CR diet (n = 76), or normal control (NC) diet (n = 75) using a computer-based random number generator. The primary outcome was the change in body mass index (BMI). The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health edBMC medicine192https://www.ebi.ac.uk/biostudies/studies/S-EPMC10210464biostudies-literatureThe effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial.PMC10210464Ruan YLiang YWu PLu ZZhang HSu JHuang QDeng GWen WMa WKang PChen XWang YYingzhangSun JAn SXu NYuan KChen HChen BLi YLi SZhang ZZhang XLin NfalseThe effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial.<h4>Background</h4>Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals.<h4>Methods</h4>A total of 302 participants were randomized to LC diet (n = 76), CR diet (n = 75), LC + CR diet (n = 76), or normal control (NC) diet (n = 75) using a computer-based random number generator. The primary outcome was the change in body mass index (BMI). The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health ed2023-01-01T00:00:00Z2023 May2025-04-21T21:21:00.893Z2025-04-05T18:18:31.695ZS-EPMC102104643722627110.1186/s12916-023-02869-9