{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Sun W"],"pubmed_abstract":["<h4>Background</h4>Changes in gene expression levels during brain development are thought to have played an important role in the evolution of human cognition. With the advent of high-throughput sequencing technologies, changes in brain developmental expression patterns, as well as human-specific brain gene expression, have been characterized. However, interpreting the origin of evolutionarily advanced cognition in human brains requires a deeper understanding of the regulation of gene expression, including the epigenomic context, along the primate genome. Here, we used chromatin immunoprecipitation sequencing (ChIP-seq) to measure the genome-wide profiles of histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 acetylation (H3K27ac), both of which are associated with transc"],"journal":["BMC biology"],"pagination":["123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10210484"],"repository":["biostudies-literature"],"pubmed_title":["Epigenetic regulation of human-specific gene expression in the prefrontal cortex."],"pmcid":["PMC10210484"],"pubmed_authors":["Liu X","Xie G","Jiang X","Sun W","Han D","Khaitovich P"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic regulation of human-specific gene expression in the prefrontal cortex.","description":"<h4>Background</h4>Changes in gene expression levels during brain development are thought to have played an important role in the evolution of human cognition. With the advent of high-throughput sequencing technologies, changes in brain developmental expression patterns, as well as human-specific brain gene expression, have been characterized. However, interpreting the origin of evolutionarily advanced cognition in human brains requires a deeper understanding of the regulation of gene expression, including the epigenomic context, along the primate genome. Here, we used chromatin immunoprecipitation sequencing (ChIP-seq) to measure the genome-wide profiles of histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 acetylation (H3K27ac), both of which are associated with transc","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-21T21:18:19.194Z","creation":"2025-04-05T18:18:53.058Z"},"accession":"S-EPMC10210484","cross_references":{"pubmed":["37226244"],"doi":["10.1186/s12915-023-01612-3"]}}