biostudies-literatureAmarikwa LNEI NIH HHSNational Institute of Health858-864https://www.ebi.ac.uk/biostudies/studies/S-EPMC10211488biostudies-literatureUnknown108(4)<h4>Context</h4>Graves orbitopathy (GO) or thyroid eye disease is a potentially sight-threatening and disfiguring autoimmune disease. Teprotumumab is a monoclonal antibody against the insulin-like growth factor-I receptor that was recently approved for GO treatment. Hyperglycemia is a recognized adverse event of teprotumumab, occurring in 10% of patients in 2 recent randomized controlled trials.<h4>Objective</h4>Our study aimed to report the incidence, severity, management, and longitudinal glycemic changes in patients treated with teprotumumab in an academic practice cohort.<h4>Methods</h4>This longitudinal, observational study included all consecutive patients treated with teprotumumab between March 2020 and May 2022 at 1 institution. Hemoglobin A1c (HbA1c) was measured every 3 months.<hThe Journal of clinical endocrinology and metabolismTeprotumumab-Related Hyperglycemia.PMC10211488P30 EY026877NIH P30 026877Kim SHKossler ALDosiou CMohamed AAmarikwa LfalseTeprotumumab-Related Hyperglycemia.<h4>Context</h4>Graves orbitopathy (GO) or thyroid eye disease is a potentially sight-threatening and disfiguring autoimmune disease. Teprotumumab is a monoclonal antibody against the insulin-like growth factor-I receptor that was recently approved for GO treatment. Hyperglycemia is a recognized adverse event of teprotumumab, occurring in 10% of patients in 2 recent randomized controlled trials.<h4>Objective</h4>Our study aimed to report the incidence, severity, management, and longitudinal glycemic changes in patients treated with teprotumumab in an academic practice cohort.<h4>Methods</h4>This longitudinal, observational study included all consecutive patients treated with teprotumumab between March 2020 and May 2022 at 1 institution. Hemoglobin A1c (HbA1c) was measured every 3 months.<h2023-01-01T00:00:00Z2023 Mar2025-05-29T20:47:25.989Z2025-05-29T20:47:25.989ZS-EPMC102114883630033310.1210/clinem/dgac627