{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roshan P"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","U.S. Department of Health & Human Services | NIH | National Cancer Institute","NCI NIH HHS","U.S. Department of Health & Human Services | NIH | NIH Office of the Director","NIGMS NIH HHS","NIH HHS"],"pagination":["3008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10212944"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Errors in chromosome segregation underlie genomic instability associated with cancers. Resolution of replication and recombination intermediates and protection of vulnerable single-stranded DNA (ssDNA) intermediates during mitotic progression requires the ssDNA binding protein Replication Protein A (RPA). However, the mechanisms that regulate RPA specifically during unperturbed mitotic progression are poorly resolved. RPA is a heterotrimer composed of RPA70, RPA32 and RPA14 subunits and is predominantly regulated through hyperphosphorylation of RPA32 in response to DNA damage. Here, we have uncovered a mitosis-specific regulation of RPA by Aurora B kinase. Aurora B phosphorylates Ser-384 in the DNA binding domain B of the large RPA70 subunit and highlights a mode of regulation distinct fro"],"journal":["Nature communications"],"pubmed_title":["An Aurora B-RPA signaling axis secures chromosome segregation fidelity."],"pmcid":["PMC10212944"],"funding_grant_id":["F99 CA274696","R01 GM133967","R01 GM130746","OD28650","S10 OD028650","GM130746","OD030343","GM149320","R35 GM149320","GM143179","S10 OD030343","GM103474","P30 CA091842","CA274696","GM133967","P20 GM103474","R01 GM143179"],"pubmed_authors":["Kuppa S","Kaushik V","Bothner B","Antony E","Pokhrel N","Roshan P","Chadda R","Biswas A","Origanti S","Mattice JR","Tumala BR"],"additional_accession":[]},"is_claimable":false,"name":"An Aurora B-RPA signaling axis secures chromosome segregation fidelity.","description":"Errors in chromosome segregation underlie genomic instability associated with cancers. Resolution of replication and recombination intermediates and protection of vulnerable single-stranded DNA (ssDNA) intermediates during mitotic progression requires the ssDNA binding protein Replication Protein A (RPA). However, the mechanisms that regulate RPA specifically during unperturbed mitotic progression are poorly resolved. RPA is a heterotrimer composed of RPA70, RPA32 and RPA14 subunits and is predominantly regulated through hyperphosphorylation of RPA32 in response to DNA damage. Here, we have uncovered a mitosis-specific regulation of RPA by Aurora B kinase. Aurora B phosphorylates Ser-384 in the DNA binding domain B of the large RPA70 subunit and highlights a mode of regulation distinct fro","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-05-28T16:45:21.013Z","creation":"2025-04-04T03:42:04.207Z"},"accession":"S-EPMC10212944","cross_references":{"pubmed":["37230964"],"doi":["10.1038/s41467-023-38711-2"]}}