{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Pattinson A"],"pubmed_abstract":["<i>Burkholderia pseudomallei</i> is the causative agent of the tropical disease, melioidosis. It is intrinsically resistant to many antimicrobials and treatment requires an onerous regimen of intravenous and orally administered drugs. Relapse of disease and high rates of mortality following treatment are common, demonstrating the need for new anti-<i>Burkholderia</i> agents. The cationic bola-amphiphile, 12,12'-(dodecane-1,12-diyl) bis (9-amino-1,2,3,4-tetrahydroacridinium), referred to as 12-bis-THA, is a molecule with the potential to treat <i>Burkholderia</i> infections. 12-bis-THA spontaneously forms cationic nanoparticles that bind anionic phospholipids in the prokaryotic membrane and are readily internalized. In this study, we examine the antimicrobial activity of 12-bis-THA against "],"journal":["Frontiers in microbiology"],"pagination":["1092230"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10213367"],"repository":["biostudies-literature"],"pubmed_title":["Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against <i>Burkholderia thailandensis</i>."],"pmcid":["PMC10213367"],"pubmed_authors":["McArthur M","Bahia S","Le Gall G","Morris CJ","Harding SV","Pattinson A"],"additional_accession":[]},"is_claimable":false,"name":"Using a multi-omic approach to investigate the mechanism of 12-bis-THA activity against <i>Burkholderia thailandensis</i>.","description":"<i>Burkholderia pseudomallei</i> is the causative agent of the tropical disease, melioidosis. It is intrinsically resistant to many antimicrobials and treatment requires an onerous regimen of intravenous and orally administered drugs. Relapse of disease and high rates of mortality following treatment are common, demonstrating the need for new anti-<i>Burkholderia</i> agents. The cationic bola-amphiphile, 12,12'-(dodecane-1,12-diyl) bis (9-amino-1,2,3,4-tetrahydroacridinium), referred to as 12-bis-THA, is a molecule with the potential to treat <i>Burkholderia</i> infections. 12-bis-THA spontaneously forms cationic nanoparticles that bind anionic phospholipids in the prokaryotic membrane and are readily internalized. In this study, we examine the antimicrobial activity of 12-bis-THA against ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T13:55:04.612Z","creation":"2024-11-21T08:25:00.434Z"},"accession":"S-EPMC10213367","cross_references":{"pubmed":["37252207"],"doi":["10.3389/fmicb.2022.1092230"]}}