{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Phylactou M"],"pubmed_abstract":["<h4>Background</h4>Free ionized calcium (Ca<sup>2+</sup>) is the biologically active component of total calcium (TCa) and hence responsible for its biological action. TCa is routinely adjusted for albumin using several formulae (e.g. James, Orell, Payne and Berry) to more closely reflect Ca<sup>2+</sup>. Here, we derive a novel formula to estimate Ca<sup>2+</sup> and compare its performance to established formulae.<h4>Methods</h4><i>Cohort for prediction of Ca<sup>2+</sup></i>: 2806 serum samples (TCa) taken contemporaneously with blood gas samples (Ca<sup>2+</sup>) at Imperial College Healthcare NHS Trust were used to derive formulae to estimate Ca<sup>2+</sup> using multivariable linear regression. <i>Cohort for prediction of PTH:</i> Performance of novel and existing formulae to predict"],"journal":["Frontiers in endocrinology"],"pagination":["1070443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10213740"],"repository":["biostudies-literature"],"pubmed_title":["Derivation and comparison of formulae for the adjustment of total calcium."],"pmcid":["PMC10213740"],"pubmed_authors":["Salih A","Phylactou M","Dhillo WS","Clarke SA","Labib M","Abbara A","Tan T","Moore P","Comninos AN","Cegla J","Eng PC"],"additional_accession":[]},"is_claimable":false,"name":"Derivation and comparison of formulae for the adjustment of total calcium.","description":"<h4>Background</h4>Free ionized calcium (Ca<sup>2+</sup>) is the biologically active component of total calcium (TCa) and hence responsible for its biological action. TCa is routinely adjusted for albumin using several formulae (e.g. James, Orell, Payne and Berry) to more closely reflect Ca<sup>2+</sup>. Here, we derive a novel formula to estimate Ca<sup>2+</sup> and compare its performance to established formulae.<h4>Methods</h4><i>Cohort for prediction of Ca<sup>2+</sup></i>: 2806 serum samples (TCa) taken contemporaneously with blood gas samples (Ca<sup>2+</sup>) at Imperial College Healthcare NHS Trust were used to derive formulae to estimate Ca<sup>2+</sup> using multivariable linear regression. <i>Cohort for prediction of PTH:</i> Performance of novel and existing formulae to predict","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-22T21:56:18.174Z","creation":"2025-04-06T03:54:19.843Z"},"accession":"S-EPMC10213740","cross_references":{"pubmed":["37251673"],"doi":["10.3389/fendo.2023.1070443"]}}