{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thevendran R"],"funding":["Technology Development Fund 1 grant of Ministry of Science, Technology and Innovation"],"pagination":["722"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10215423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Dengue infection, caused by the dengue virus, is a global threat which requires immediate attention and appropriate disease management. The current diagnosis of dengue infection is largely based on viral isolation, RT-PCR and serology-based detection, which are time-consuming and expensive, and require trained personnel. For early diagnosis of dengue, the direct detection of a dengue antigenic target is efficacious, and one such target is NS1. NS1-based detection is primarily antibody-centric and is beset by drawbacks pertaining to antibodies such as the high cost of synthesis and large batch-to-batch variation. Aptamers are potential surrogates of antibodies and are much cheaper, without exhibiting batch-to-batch variation. Given these advantages, we sought to isolate RNA aptamers against"],"journal":["Biology"],"pubmed_title":["The Diagnostic Potential of RNA Aptamers against the NS1 Protein of Dengue Virus Serotype 2."],"pmcid":["PMC10215423"],"funding_grant_id":["TDF03211027"],"pubmed_authors":["Leighton G","Tang TH","Citartan M","Mutombwera A","Thevendran R","Rogini S","Shigdar S"],"additional_accession":[]},"is_claimable":false,"name":"The Diagnostic Potential of RNA Aptamers against the NS1 Protein of Dengue Virus Serotype 2.","description":"Dengue infection, caused by the dengue virus, is a global threat which requires immediate attention and appropriate disease management. The current diagnosis of dengue infection is largely based on viral isolation, RT-PCR and serology-based detection, which are time-consuming and expensive, and require trained personnel. For early diagnosis of dengue, the direct detection of a dengue antigenic target is efficacious, and one such target is NS1. NS1-based detection is primarily antibody-centric and is beset by drawbacks pertaining to antibodies such as the high cost of synthesis and large batch-to-batch variation. Aptamers are potential surrogates of antibodies and are much cheaper, without exhibiting batch-to-batch variation. Given these advantages, we sought to isolate RNA aptamers against","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-04T19:29:47.684Z","creation":"2025-04-04T19:29:47.684Z"},"accession":"S-EPMC10215423","cross_references":{"pubmed":["37237536"],"doi":["10.3390/biology12050722"]}}