biostudies-literatureLiu DFundamental Research Funds for the Central UniversitiesKnowledge Innovation Program of Wuhan-Basic ResearchNational Natural Science Foundation of China1298https://www.ebi.ac.uk/biostudies/studies/S-EPMC10215535biostudies-literatureUnknown11(5)Vestibular compensation is a natural behavioral recovery process following unilateral vestibular injury. Understanding the mechanism can considerably enhance vestibular disorder therapy and advance the adult central nervous system functional plasticity study after injury. The cerebellum, particularly the flocculonodular lobe, tightly modulates the vestibular nucleus, the center for vestibular compensation; however, it is still unclear if the flocculus on both sides is involved in vestibular compensation. Here we report that the unipolar brush cells (UBCs) in the flocculus are modulated by unilateral labyrinthectomy (UL). UBCs are excitatory interneurons targeting granule cells to provide feedforward innervation to the Purkinje cells, the primary output neurons in the cerebellum. According BiomedicinesDifferential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.PMC1021553582171152818737012022020801010458YCJJ202201040Zhou LChen JLu YTian ELiu DZhang SWang JKong WfalseDifferential Modulation of Cerebellar Flocculus Unipolar Brush Cells during Vestibular Compensation.Vestibular compensation is a natural behavioral recovery process following unilateral vestibular injury. Understanding the mechanism can considerably enhance vestibular disorder therapy and advance the adult central nervous system functional plasticity study after injury. The cerebellum, particularly the flocculonodular lobe, tightly modulates the vestibular nucleus, the center for vestibular compensation; however, it is still unclear if the flocculus on both sides is involved in vestibular compensation. Here we report that the unipolar brush cells (UBCs) in the flocculus are modulated by unilateral labyrinthectomy (UL). UBCs are excitatory interneurons targeting granule cells to provide feedforward innervation to the Purkinje cells, the primary output neurons in the cerebellum. According 2023-01-01T00:00:00Z2023 Apr2025-04-05T14:15:09.225Z2025-04-05T14:15:09.225ZS-EPMC102155353723896710.3390/biomedicines11051298