biostudies-literatureThompson SAAustinPx1281https://www.ebi.ac.uk/biostudies/studies/S-EPMC10215938biostudies-literatureUnknown11(5)This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (<i>w</i>/<i>w</i>) ratio of hypromellose acetate succinate and povidone to form a single-phase polymer alloy with unique properties. Ivacaftor amorphous solid dispersions comprising either a polymer, an unprocessed polymer blend, or the polymer alloy were processed by KinetiSol and examined for amorphicity, dissolution performance, physical stability, and molecular interactions. A polymer alloy ivacaftor solid dispersion with a drug loading of 50% <i>w</i>/<i>w</i> was feasible versus 40% for the other compositions. Dissolution in fasted simulated intestinal fluid revealed thatBiomedicinesPre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution.PMC10215938N/AWilliams ROMiller DAThompson SAKucera SUDavis DAfalsePre-Processing a Polymer Blend into a Polymer Alloy by KinetiSol Enables Increased Ivacaftor Amorphous Solid Dispersion Drug Loading and Dissolution.This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (<i>w</i>/<i>w</i>) ratio of hypromellose acetate succinate and povidone to form a single-phase polymer alloy with unique properties. Ivacaftor amorphous solid dispersions comprising either a polymer, an unprocessed polymer blend, or the polymer alloy were processed by KinetiSol and examined for amorphicity, dissolution performance, physical stability, and molecular interactions. A polymer alloy ivacaftor solid dispersion with a drug loading of 50% <i>w</i>/<i>w</i> was feasible versus 40% for the other compositions. Dissolution in fasted simulated intestinal fluid revealed that2023-01-01T00:00:00Z2023 Apr2025-04-04T20:56:33.141Z2025-04-04T20:56:33.141ZS-EPMC102159383723895210.3390/biomedicines11051281