biostudies-literatureZhang LScience and Technology Project of GuangxiInnovation Project of Guangxi Graduate EducationGuilin University of Technology509https://www.ebi.ac.uk/biostudies/studies/S-EPMC10216006biostudies-literatureUnknown13(5)The efficacies and toxicities of chiral drug enantiomers are often dissimilar, necessitating chiral recognition methods. Herein, a polylysine-phenylalanine complex framework was used to prepare molecularly imprinted polymers (MIPs) as sensors with enhanced specific recognition capabilities for levo-lansoprazole. The properties of the MIP sensor were investigated using Fourier-transform infrared spectroscopy and electrochemical methods. The optimal sensor performance was achieved by applying self-assembly times of 30.0 and 25.0 min for the complex framework and levo-lansoprazole, respectively, eight electropolymerization cycles with <i>o</i>-phenylenediamine as the functional monomer, an elution time of 5.0 min using an ethanol/acetic acid/H₂O mixture (2/3/8, <i>V</i>/<i>V</i>/<iBiosensorsDevelopment of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine-Phenylalanine Complex Framework Conformational Separation.PMC10216006Guike AD19110059GUTQDJJ2016024YCSW2022332Li JLi DOuyang HZhang LWang ZYuan YfalseDevelopment of Levo-Lansoprazole Chiral Molecularly Imprinted Polymer Sensor Based on the Polylysine-Phenylalanine Complex Framework Conformational Separation.The efficacies and toxicities of chiral drug enantiomers are often dissimilar, necessitating chiral recognition methods. Herein, a polylysine-phenylalanine complex framework was used to prepare molecularly imprinted polymers (MIPs) as sensors with enhanced specific recognition capabilities for levo-lansoprazole. The properties of the MIP sensor were investigated using Fourier-transform infrared spectroscopy and electrochemical methods. The optimal sensor performance was achieved by applying self-assembly times of 30.0 and 25.0 min for the complex framework and levo-lansoprazole, respectively, eight electropolymerization cycles with <i>o</i>-phenylenediamine as the functional monomer, an elution time of 5.0 min using an ethanol/acetic acid/H₂O mixture (2/3/8, <i>V</i>/<i>V</i>/<i2023-01-01T00:00:00Z2023 Apr2025-04-04T20:56:25.495Z2025-04-04T20:56:25.495ZS-EPMC102160063723287010.3390/bios13050509