{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu L"],"funding":["BLRD VA","NIA NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIAMS NIH HHS","NIH HHS"],"pagination":["689-705.e4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10216894"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["Exercise has the ability to rejuvenate stem cells and improve tissue regeneration in aging animals. However, the cellular and molecular changes elicited by exercise have not been systematically studied across a broad range of cell types in stem cell compartments. We subjected young and old mice to aerobic exercise and generated a single-cell transcriptomic atlas of muscle, neural, and hematopoietic stem cells with their niche cells and progeny, complemented by whole transcriptome analysis of single myofibers. We found that exercise ameliorated the upregulation of a number of inflammatory pathways associated with old age and restored aspects of intercellular communication mediated by immune cells within these stem cell compartments. Exercise has a profound impact on the composition and tran"],"journal":["Cell stem cell"],"pubmed_title":["Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging."],"pmcid":["PMC10216894"],"funding_grant_id":["P30 DK116074","R01 HL130020","R01 AG071783","P01 AG036695","P30 CA125123","R37 AG023806","I01 BX002324","R01 DK092883","S10 OD025212","R01 HL126527","R01 AG047820","R01 AR073248","R01 AG068667"],"pubmed_authors":["Brunet A","Tian L","Mao M","Rodriguez-Mateo C","Liu L","Wu JC","Rando TA","Lieu A","Jeong M","Kim S","Wang M","Buckley MT","Goodell MA","Ishak HD","Reyes JM","Kang J"],"additional_accession":[]},"is_claimable":false,"name":"Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging.","description":"Exercise has the ability to rejuvenate stem cells and improve tissue regeneration in aging animals. However, the cellular and molecular changes elicited by exercise have not been systematically studied across a broad range of cell types in stem cell compartments. We subjected young and old mice to aerobic exercise and generated a single-cell transcriptomic atlas of muscle, neural, and hematopoietic stem cells with their niche cells and progeny, complemented by whole transcriptome analysis of single myofibers. We found that exercise ameliorated the upregulation of a number of inflammatory pathways associated with old age and restored aspects of intercellular communication mediated by immune cells within these stem cell compartments. Exercise has a profound impact on the composition and tran","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-06-02T02:11:26.471Z","creation":"2026-04-13T03:13:00.243Z"},"accession":"S-EPMC10216894","cross_references":{"pubmed":["37080206"],"doi":["10.1016/j.stem.2023.03.016"]}}