{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Demir S"],"funding":["Hacettepe University"],"pagination":["1729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10217085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["<h4>Background</h4>IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.<h4>Objective</h4>to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.<h4>Methods</h4>Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to investigate the alterations in plasma proteomic profiles. For the bioinformatics analyses, databases including Uniprot, PANTHER, KEGG, Reactome, Cytoscape, and IntAct were used.<h4>Results</h4>Among the 418 prote"],"journal":["Diagnostics (Basel, Switzerland)"],"pubmed_title":["Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis."],"pmcid":["PMC10217085"],"funding_grant_id":["TCP-2020-18195"],"pubmed_authors":["Sag E","Bilginer Y","Lay I","Ozen S","Yet I","Demir S","Sardan Ekiz M","Celikbicak O"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis.","description":"<h4>Background</h4>IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.<h4>Objective</h4>to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.<h4>Methods</h4>Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to investigate the alterations in plasma proteomic profiles. For the bioinformatics analyses, databases including Uniprot, PANTHER, KEGG, Reactome, Cytoscape, and IntAct were used.<h4>Results</h4>Among the 418 prote","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-04T20:57:39.391Z","creation":"2025-04-04T20:57:39.391Z"},"accession":"S-EPMC10217085","cross_references":{"pubmed":["37238213"],"doi":["10.3390/diagnostics13101729"]}}