biostudies-literatureDemir SHacettepe University1729https://www.ebi.ac.uk/biostudies/studies/S-EPMC10217085biostudies-literatureUnknown13(10)<h4>Background</h4>IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.<h4>Objective</h4>to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.<h4>Methods</h4>Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to investigate the alterations in plasma proteomic profiles. For the bioinformatics analyses, databases including Uniprot, PANTHER, KEGG, Reactome, Cytoscape, and IntAct were used.<h4>Results</h4>Among the 418 proteDiagnostics (Basel, Switzerland)Plasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis.PMC10217085TCP-2020-18195Sag EBilginer YLay IOzen SYet IDemir SSardan Ekiz MCelikbicak OfalsePlasma Proteomic Analysis Reveals the Potential Role of Lectin and Alternative Complement Pathways in IgA Vasculitis Pathogenesis.<h4>Background</h4>IgA vasculitis (IgAV) is the most common form of childhood vasculitis. A better understanding of its pathophysiology is required to identify new potential biomarkers and treatment targets.<h4>Objective</h4>to assess the underlying molecular mechanisms in the pathogenesis of IgAV using an untargeted proteomics approach.<h4>Methods</h4>Thirty-seven IgAV patients and five healthy controls were enrolled. Plasma samples were collected on the day of diagnosis before any treatment was initiated. We used nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to investigate the alterations in plasma proteomic profiles. For the bioinformatics analyses, databases including Uniprot, PANTHER, KEGG, Reactome, Cytoscape, and IntAct were used.<h4>Results</h4>Among the 418 prote2023-01-01T00:00:00Z2023 May2025-04-04T20:57:39.391Z2025-04-04T20:57:39.391ZS-EPMC102170853723821310.3390/diagnostics13101729