{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(5)"],"submitter":["Moawadh MS"],"pubmed_abstract":["The regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of BCL2 and BAX. The <i>Bax-248G>A</i> and <i>Bcl-2-938 C>A</i> polymorphic variations in the promoter sequences of the <i>Bax</i> and <i>Bcl-2</i> gene have been recently associated with low <i>Bax</i> expression, progression to advanced stages, treatment resistance, and shortened overall survival rate in some hematological malignancies, including chronic myeloid leukemia (CML) and other myeloproliferative neoplasms. Chronic inflammation has been linked to various stages of carcinogenesis wherein pro-inflammatory cytokines play diverse roles in influencing cancer microenvironment leading to cell invasion and cancer progression. Cytokines such as TNF-α and IL-8 have been implicated in cancer gro"],"journal":["Current issues in molecular biology"],"pagination":["3933-3952"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10217376"],"repository":["biostudies-literature"],"pubmed_title":["Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (<i>Bcl-2/Bax</i>) and Proinflammatory Cytokine (<i>TNF-α/IL-8</i>) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study."],"pmcid":["PMC10217376"],"pubmed_authors":["Asim O","Mir R","Moawadh MS","Ullah MF","Tayeb FJ"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Evaluation of the Impact of Polymorphic Variants in Apoptotic (<i>Bcl-2/Bax</i>) and Proinflammatory Cytokine (<i>TNF-α/IL-8</i>) Genes on the Susceptibility and Progression of Myeloproliferative Neoplasms: A Case-Control Biomarker Study.","description":"The regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of BCL2 and BAX. The <i>Bax-248G>A</i> and <i>Bcl-2-938 C>A</i> polymorphic variations in the promoter sequences of the <i>Bax</i> and <i>Bcl-2</i> gene have been recently associated with low <i>Bax</i> expression, progression to advanced stages, treatment resistance, and shortened overall survival rate in some hematological malignancies, including chronic myeloid leukemia (CML) and other myeloproliferative neoplasms. Chronic inflammation has been linked to various stages of carcinogenesis wherein pro-inflammatory cytokines play diverse roles in influencing cancer microenvironment leading to cell invasion and cancer progression. Cytokines such as TNF-α and IL-8 have been implicated in cancer gro","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-22T18:23:34.208Z","creation":"2025-02-19T03:25:30.951Z"},"accession":"S-EPMC10217376","cross_references":{"pubmed":["37232720"],"doi":["10.3390/cimb45050251"]}}