{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sanchez-Estrada R"],"funding":["Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional (IPN)","Consejo Nacional de Ciencia y Tecnología (CONACyT), México"],"pagination":["1023"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10218544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["The slow-growing, nontuberculous mycobacterium <i>Mycobacterium kumamotonense</i> possesses two rRNA operons, <i>rrnA</i> and <i>rrnB</i>, located downstream from the <i>murA</i> and <i>tyrS</i> genes, respectively. Here, we report the sequence and organization of the promoter regions of these two <i>rrn</i> operons. In the <i>rrnA</i> operon, transcription can be initiated from the two promoters, named P1 <i>rrnA</i> and PCL1, while in <i>rrnB</i>, transcription can only start from one, called P1 <i>rrnB</i>. Both <i>rrn</i> operons show a similar organization to the one described in <i>Mycobacterium celatum</i> and <i>Mycobacterium smegmatis</i>. Furthermore, by qRT-PCR analyses of the products generated from each promoter, we report that stress conditions such as starvation, hypoxia, an"],"journal":["Genes"],"pubmed_title":["Organization and Characterization of the Promoter Elements of the rRNA Operons in the Slow-Growing Pathogen <i>Mycobacterium kumamotonense</i>."],"pmcid":["PMC10218544"],"funding_grant_id":["SIP20231561 (SR-G)","CB-2015-01-255181 (SR-G)","SIP20230257 (JFC-C)"],"pubmed_authors":["Gonzalez-Y-Merchand JA","Garcia-Morales L","Cerna-Cortes JF","Sanchez-Estrada R","Rivera-Gutierrez S","Menendez MC","Leon-Solis LE","Garcia MJ","Mendez-Guerrero O"],"additional_accession":[]},"is_claimable":false,"name":"Organization and Characterization of the Promoter Elements of the rRNA Operons in the Slow-Growing Pathogen <i>Mycobacterium kumamotonense</i>.","description":"The slow-growing, nontuberculous mycobacterium <i>Mycobacterium kumamotonense</i> possesses two rRNA operons, <i>rrnA</i> and <i>rrnB</i>, located downstream from the <i>murA</i> and <i>tyrS</i> genes, respectively. Here, we report the sequence and organization of the promoter regions of these two <i>rrn</i> operons. In the <i>rrnA</i> operon, transcription can be initiated from the two promoters, named P1 <i>rrnA</i> and PCL1, while in <i>rrnB</i>, transcription can only start from one, called P1 <i>rrnB</i>. Both <i>rrn</i> operons show a similar organization to the one described in <i>Mycobacterium celatum</i> and <i>Mycobacterium smegmatis</i>. Furthermore, by qRT-PCR analyses of the products generated from each promoter, we report that stress conditions such as starvation, hypoxia, an","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-04-08T12:33:42.394Z","creation":"2025-04-19T15:07:05.667Z"},"accession":"S-EPMC10218544","cross_references":{"pubmed":["37239384"],"doi":["10.3390/genes14051023"]}}