biostudies-literatureUnknown9(6)Fan X<h4>Background</h4>The study aimed to identify the relations of the absolute lymphocyte count (ALC) nadir during prophylactic cranial irradiation (PCI) and patient outcomes in limited-stage small cell lung cancer (LS-SCLC).<h4>Methods</h4>We analyzed 268 L S-SCLC patients who underwent PCI from 2012 to 2019. ALC values were collected prior, during, and 3 months post PCI. Kaplan-Meier and Cox regression analyses were performed to assess the relation of ALC to patient prognosis. Two nomograms were developed on the basis of clinical variables for survival prediction.<h4>Results</h4>Compared with the ALC before PCI (1.13 × 10⁹ cells/L), the ALC nadir during PCI was significantly reduced by 0.68 × 10⁹ cells/L (P < 0.001) and raised to 1.02 × 10⁹ cells/L 3 months post PCI. Patients with a low ALC nadir during PCI (<0.68 × 10⁹ cells/L) had inferior progression free survival (PFS) (median PFS: 17.2 <i>m</i> vs. 43.7 <i>m</i>, P = 0.019) and overall survival (OS) (median OS: 29.0 <i>m</i> vs 39.1 <i>m</i>, P = 0.012). Multivariate Cox analysis revealed that age, smoking history, clinical stage, and ALC nadir were independent OS (P = 0.006, P = 0.005, P < 0.001 and P = 0.027, respectively), as well as independent PFS predictors (P = 0.032, P = 0.012, P = 0.012 and P = 0.018, respectively). After internal cross-validation, the corrected concordance indices of the predictive nomograms for PFS and OS were 0.637 and 0.663, respectively.<h4>Conclusion</h4>LS-SCLC patients with a low ALC nadir during PCI likely have worse survival outcomes. Dynamic evaluation of the ALC during PCI is recommended for LS-SCLC patients.Heliyone16483https://www.ebi.ac.uk/biostudies/studies/S-EPMC10220366biostudies-literatureProphylactic cranial irradiation-related lymphopenia affects survival in patients with limited-stage small cell lung cancer.PMC10220366Fan XYang LWang SZou BQin WFan BWang LfalseProphylactic cranial irradiation-related lymphopenia affects survival in patients with limited-stage small cell lung cancer.<h4>Background</h4>The study aimed to identify the relations of the absolute lymphocyte count (ALC) nadir during prophylactic cranial irradiation (PCI) and patient outcomes in limited-stage small cell lung cancer (LS-SCLC).<h4>Methods</h4>We analyzed 268 L S-SCLC patients who underwent PCI from 2012 to 2019. ALC values were collected prior, during, and 3 months post PCI. Kaplan-Meier and Cox regression analyses were performed to assess the relation of ALC to patient prognosis. Two nomograms were developed on the basis of clinical variables for survival prediction.<h4>Results</h4>Compared with the ALC before PCI (1.13 × 10⁹ cells/L), the ALC nadir during PCI was significantly reduced by 0.68 × 10⁹ cells/L (P < 0.001) and raised to 1.02 × 10⁹ cells/L 3 months post PCI. Patients with a low ALC nadir during PCI (<0.68 × 10⁹ cells/L) had inferior progression free survival (PFS) (median PFS: 17.2 <i>m</i> vs. 43.7 <i>m</i>, P = 0.019) and overall survival (OS) (median OS: 29.0 <i>m</i> vs 39.1 <i>m</i>, P = 0.012). Multivariate Cox analysis revealed that age, smoking history, clinical stage, and ALC nadir were independent OS (P = 0.006, P = 0.005, P < 0.001 and P = 0.027, respectively), as well as independent PFS predictors (P = 0.032, P = 0.012, P = 0.012 and P = 0.018, respectively). After internal cross-validation, the corrected concordance indices of the predictive nomograms for PFS and OS were 0.637 and 0.663, respectively.<h4>Conclusion</h4>LS-SCLC patients with a low ALC nadir during PCI likely have worse survival outcomes. Dynamic evaluation of the ALC during PCI is recommended for LS-SCLC patients.2023-01-01T00:00:00Z2023 Jun2025-04-22T21:58:09.977Z2025-04-06T03:55:21.019ZS-EPMC102203663725147710.1016/j.heliyon.2023.e16483