biostudies-literatureUnknown28(10)Ambra RThe purpose of this review is to systematically examine the scientific evidence investigating selenium's relationship with COVID-19, aiming to support, or refute, the growing hypothesis that supplementation could prevent COVID-19 etiopathogenesis. In fact, immediately after the beginning of the COVID-19 pandemic, several speculative reviews suggested that selenium supplementation in the general population could act as a silver bullet to limit or even prevent the disease. Instead, a deep reading of the scientific reports on selenium and COVID-19 that are available to date supports neither the specific role of selenium in COVID-19 severity, nor the role of its supplementation in the prevention disease onset, nor its etiology.Molecules (Basel, Switzerland)4130https://www.ebi.ac.uk/biostudies/studies/S-EPMC10222736biostudies-literatureCould Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.PMC10222736Venneria EAmbra RMelloni SfalseCould Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies.The purpose of this review is to systematically examine the scientific evidence investigating selenium's relationship with COVID-19, aiming to support, or refute, the growing hypothesis that supplementation could prevent COVID-19 etiopathogenesis. In fact, immediately after the beginning of the COVID-19 pandemic, several speculative reviews suggested that selenium supplementation in the general population could act as a silver bullet to limit or even prevent the disease. Instead, a deep reading of the scientific reports on selenium and COVID-19 that are available to date supports neither the specific role of selenium in COVID-19 severity, nor the role of its supplementation in the prevention disease onset, nor its etiology.2023-01-01T00:00:00Z2023 May2025-04-04T21:15:02.692Z2024-11-11T18:54:19.699ZS-EPMC102227363724187010.3390/molecules28104130