biostudies-literatureUllah SKing Saud University693https://www.ebi.ac.uk/biostudies/studies/S-EPMC10224544biostudies-literatureUnknown16(5)Six heteroleptic Cu(II) carboxylates (<b>1</b>-<b>6</b>) were prepared by reacting 2-chlorophenyl acetic acid (<b>L¹</b>), 3-chlorophenyl acetic acid (<b>L²</b>), and substituted pyridine (2-cyanopyridine and 2-chlorocyanopyridine). The solid-state behavior of the complexes was described via vibrational spectroscopy (FT-IR), which revealed that the carboxylate moieties adopted different coordination modes around the Cu(II) center. A paddlewheel dinuclear structure with distorted square pyramidal geometry was elucidated from the crystal data for complexes <b>2</b> and <b>5</b> with substituted pyridine moieties at the axial positions. The presence of irreversible metal-centered oxidation reduction peaks confirms the electroactive nature of the complexes. A relatively hPharmaceuticals (Basel, Switzerland)Synthesis, Structural Elucidation and Pharmacological Applications of Cu(II) Heteroleptic Carboxylates.PMC10224544RSP2023R357Rehman MUUllah SNaz SZubair MSirajuddin MAli SKubicki MZargar SUllah ZWani TAMushtaq AHaider AfalseSynthesis, Structural Elucidation and Pharmacological Applications of Cu(II) Heteroleptic Carboxylates.Six heteroleptic Cu(II) carboxylates (<b>1</b>-<b>6</b>) were prepared by reacting 2-chlorophenyl acetic acid (<b>L¹</b>), 3-chlorophenyl acetic acid (<b>L²</b>), and substituted pyridine (2-cyanopyridine and 2-chlorocyanopyridine). The solid-state behavior of the complexes was described via vibrational spectroscopy (FT-IR), which revealed that the carboxylate moieties adopted different coordination modes around the Cu(II) center. A paddlewheel dinuclear structure with distorted square pyramidal geometry was elucidated from the crystal data for complexes <b>2</b> and <b>5</b> with substituted pyridine moieties at the axial positions. The presence of irreversible metal-centered oxidation reduction peaks confirms the electroactive nature of the complexes. A relatively h2023-01-01T00:00:00Z2023 May2025-05-29T16:22:12.851Z2025-05-29T16:22:12.851ZS-EPMC102245443724247610.3390/ph16050693