{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mori da Cunha MGMC"],"funding":["Fonds Wetenschappelijk Onderzoek"],"pagination":["8622"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10224946"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Vaginal birth causes pelvic floor injury which may lead to urinary incontinence. Cell therapy has been proposed to assist in functional recovery. We aim to assess if intra-arterial injection of rat mesoangioblasts (MABs) and stable Vascular Endothelial Growth Factor (VEGF)-expressing MABs, improve recovery of urethral and vaginal function following simulated vaginal delivery (SVD). Female rats (n = 86) were assigned to either injection of saline (control), allogeneic-MABs (MABs<sup>allo</sup>), autologous-MABs (MABs<sup>auto</sup>) or allogeneic-MABs transduced to stably expressed VEGF (MABs<sup>allo-VEGF</sup>). One hour after SVD, 0.5 × 10<sup>6</sup> MABs or saline were injected into the aorta. Primary outcome was urethral (7d and 14d) and vaginal (14d) function; others were bioluminesc"],"journal":["Scientific reports"],"pubmed_title":["VEGF overexpressed mesoangioblasts enhance urethral and vaginal recovery following simulated vaginal birth in rats."],"pmcid":["PMC10224946"],"funding_grant_id":["11E7920N","G069715N"],"pubmed_authors":["van der Veer BK","Cattani L","Mackova K","Koh KP","Deprest J","Sampaolesi M","Mori da Cunha MGMC","Vande Velde G","Gijsbers R","Albersen M","Giacomazzi G"],"additional_accession":[]},"is_claimable":false,"name":"VEGF overexpressed mesoangioblasts enhance urethral and vaginal recovery following simulated vaginal birth in rats.","description":"Vaginal birth causes pelvic floor injury which may lead to urinary incontinence. Cell therapy has been proposed to assist in functional recovery. We aim to assess if intra-arterial injection of rat mesoangioblasts (MABs) and stable Vascular Endothelial Growth Factor (VEGF)-expressing MABs, improve recovery of urethral and vaginal function following simulated vaginal delivery (SVD). Female rats (n = 86) were assigned to either injection of saline (control), allogeneic-MABs (MABs<sup>allo</sup>), autologous-MABs (MABs<sup>auto</sup>) or allogeneic-MABs transduced to stably expressed VEGF (MABs<sup>allo-VEGF</sup>). One hour after SVD, 0.5 × 10<sup>6</sup> MABs or saline were injected into the aorta. Primary outcome was urethral (7d and 14d) and vaginal (14d) function; others were bioluminesc","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2025-04-04T09:18:48.265Z","creation":"2025-04-04T09:18:48.265Z"},"accession":"S-EPMC10224946","cross_references":{"pubmed":["37244975"],"doi":["10.1038/s41598-023-35809-x"]}}