biostudies-literatureUnknown14Zhou G<h4>Objectives</h4> We aimed to evaluate the indeterminate rate of interferon gamma release assays (IGRAs) in the detection of latent tuberculosis infection (LTBI). <h4>Methods</h4> On 15 November 2022, we searched the PubMed® (National Library of Medicine, Bethesda, MD, USA), Embase® (Elsevier, Amsterdam, the Netherlands), and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two investigators independently extracted the study data and assessed their quality using a modified quality assessment of diagnostic accuracy studies (i.e., QUADAS-2) tool. A random-effects model was used to calculate pooled results. <h4>Results</h4> We included 403 studies involving 486,886 individuals and found that the pooled Frontiers in immunologyhttps://www.ebi.ac.uk/biostudies/studies/S-EPMC10225525biostudies-literatureIndeterminate results of interferon gamma release assays in the screening of latent tuberculosis infection: a systematic review and meta-analysisPMC10225525Xia YLi HLuo QCai SHe JGuo XZhang YSong CZhou GChen HLuo SZhou YfalseIndeterminate results of interferon gamma release assays in the screening of latent tuberculosis infection: a systematic review and meta-analysis<h4>Objectives</h4> We aimed to evaluate the indeterminate rate of interferon gamma release assays (IGRAs) in the detection of latent tuberculosis infection (LTBI). <h4>Methods</h4> On 15 November 2022, we searched the PubMed® (National Library of Medicine, Bethesda, MD, USA), Embase® (Elsevier, Amsterdam, the Netherlands), and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two investigators independently extracted the study data and assessed their quality using a modified quality assessment of diagnostic accuracy studies (i.e., QUADAS-2) tool. A random-effects model was used to calculate pooled results. <h4>Results</h4> We included 403 studies involving 486,886 individuals and found that the pooled 2023-01-01T00:00:00Z2023 Jan2025-04-19T02:37:29.942Z2025-04-19T02:37:29.942ZS-EPMC10225525